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- Publisher Website: 10.1007/s00330-020-07317-3
- Scopus: eid_2-s2.0-85091427976
- PMID: 32974689
- WOS: WOS:000572614000005
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Article: Combining high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules
Title | Combining high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules |
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Authors | |
Keywords | Interventional ultrasonography High-intensity focused ultrasound ablation Nodular goiter Ultrasonic imaging Ablation techniques |
Issue Date | 2021 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm |
Citation | European Radiology, 2021, v. 31, p. 2384-2391 How to Cite? |
Abstract | Objective
Assessing the 6-month efficacy of combined high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in benign thyroid nodules by comparing it with HIFU ablation alone.
Methods:
One hundred and eighty-one (55.2%) patients underwent HIFU alone (group I) while 147 (44.8%) underwent concomitant HIFU and PEI treatment for solid or predominantly solid nodules (group II). Intravenous sedation and analgesia were given before the start of treatment. Extent of nodule shrinkage (by volume reduction ratio (VRR)), pain scores (by 0–10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn, and nausea/vomiting were compared between the two groups.
Results:
The mean amount of ethanol injected in group II was 1.3 ± 0.7 ml. The 3- and 6-month VRR were significantly greater in group II (60.41 ± 20.49% vs. 50.13 ± 21.06%, p = 0.001; and 71.08 ± 21.25% vs. 61.37 ± 22.76%, p = 0.001, respectively), and “on-beam” treatment time was significantly shorter in group II (26.55 min vs. 30.26 min, p = 0.001). Group II patients reported significantly lower pain score during treatment (2.24 ± 3.07 vs. 4.97 ± 3.21, p < 0.001) and 2 h after treatment (2.23 ± 2.50 vs. 2.97 ± 4.39, p = 0.044). Rates of VCP, skin burn, and nausea or vomiting were not significantly different (p > 0.05).
Conclusions:
The combined HIFU and PEI approach with improved administration of intravenous sedation and analgesia was associated with a significantly better 6-month efficacy than HIFU alone in benign thyroid nodules without compromising the safety and comfort of patients. |
Persistent Identifier | http://hdl.handle.net/10722/288059 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.656 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lang, BHH | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Chiu, KWH | - |
dc.date.accessioned | 2020-10-05T12:07:16Z | - |
dc.date.available | 2020-10-05T12:07:16Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | European Radiology, 2021, v. 31, p. 2384-2391 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288059 | - |
dc.description.abstract | Objective Assessing the 6-month efficacy of combined high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in benign thyroid nodules by comparing it with HIFU ablation alone. Methods: One hundred and eighty-one (55.2%) patients underwent HIFU alone (group I) while 147 (44.8%) underwent concomitant HIFU and PEI treatment for solid or predominantly solid nodules (group II). Intravenous sedation and analgesia were given before the start of treatment. Extent of nodule shrinkage (by volume reduction ratio (VRR)), pain scores (by 0–10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn, and nausea/vomiting were compared between the two groups. Results: The mean amount of ethanol injected in group II was 1.3 ± 0.7 ml. The 3- and 6-month VRR were significantly greater in group II (60.41 ± 20.49% vs. 50.13 ± 21.06%, p = 0.001; and 71.08 ± 21.25% vs. 61.37 ± 22.76%, p = 0.001, respectively), and “on-beam” treatment time was significantly shorter in group II (26.55 min vs. 30.26 min, p = 0.001). Group II patients reported significantly lower pain score during treatment (2.24 ± 3.07 vs. 4.97 ± 3.21, p < 0.001) and 2 h after treatment (2.23 ± 2.50 vs. 2.97 ± 4.39, p = 0.044). Rates of VCP, skin burn, and nausea or vomiting were not significantly different (p > 0.05). Conclusions: The combined HIFU and PEI approach with improved administration of intravenous sedation and analgesia was associated with a significantly better 6-month efficacy than HIFU alone in benign thyroid nodules without compromising the safety and comfort of patients. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm | - |
dc.relation.ispartof | European Radiology | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.subject | Interventional ultrasonography | - |
dc.subject | High-intensity focused ultrasound ablation | - |
dc.subject | Nodular goiter | - |
dc.subject | Ultrasonic imaging | - |
dc.subject | Ablation techniques | - |
dc.title | Combining high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules | - |
dc.type | Article | - |
dc.identifier.email | Lang, BHH: Blang@hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Chiu, KWH: kwhchiu@hku.hk | - |
dc.identifier.authority | Lang, BHH=rp01828 | - |
dc.identifier.authority | Chiu, KWH=rp02074 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00330-020-07317-3 | - |
dc.identifier.pmid | 32974689 | - |
dc.identifier.scopus | eid_2-s2.0-85091427976 | - |
dc.identifier.hkuros | 315467 | - |
dc.identifier.volume | 31 | - |
dc.identifier.spage | 2384 | - |
dc.identifier.epage | 2391 | - |
dc.identifier.isi | WOS:000572614000005 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0938-7994 | - |