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Book Chapter: The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation

TitleThe Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation
Authors
KeywordsPRRs
Autophagy
TLRs
NLRs
cGAS-STING
Issue Date2019
PublisherSpringer
Citation
The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation. In Cui, J (Ed.), Autophagy Regulation of Innate Immunity, p. 79-108. Singapore: Springer, 2019 How to Cite?
AbstractPattern recognition receptors (PRRs) are sensors of exogenous and endogenous “danger” signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway can induce autophagy directly through Beclin-1 or LC3-dependent pathway, while the interactions with the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1), CD91/Calreticulin, and TLRs/HSPs are achieved by protein, Ca2+, and mitochondrial homeostasis. Autophagy presents antigens to PRRs and helps to clean the pathogens. In addition, the induced autophagy can form a negative feedback regulation of PRRs-mediated inflammation in cell/disease-specific manner to maintain homeostasis and prevent excessive inflammation. Understanding the interaction between PRRs and autophagy in a specific disease will promote drug development for immunotherapy. Here, we focus on the interactions between PRRs and autophagy and how they affect the inflammatory response.
Persistent Identifierhttp://hdl.handle.net/10722/288409
ISBN
ISSN
2021 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.244
ISI Accession Number ID
Series/Report no.Advances in Experimental Medicine and Biology ; v. 1209

 

DC FieldValueLanguage
dc.contributor.authorZhu, Y-
dc.contributor.authorDeng, J-
dc.contributor.authorNan, ML-
dc.contributor.authorZhang, J-
dc.contributor.authorOkekunle, A-
dc.contributor.authorLi, JY-
dc.contributor.authorYu, XQ-
dc.contributor.authorWang, PH-
dc.date.accessioned2020-10-05T12:12:28Z-
dc.date.available2020-10-05T12:12:28Z-
dc.date.issued2019-
dc.identifier.citationThe Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation. In Cui, J (Ed.), Autophagy Regulation of Innate Immunity, p. 79-108. Singapore: Springer, 2019-
dc.identifier.isbn9789811506062-
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/10722/288409-
dc.description.abstractPattern recognition receptors (PRRs) are sensors of exogenous and endogenous “danger” signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway can induce autophagy directly through Beclin-1 or LC3-dependent pathway, while the interactions with the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1), CD91/Calreticulin, and TLRs/HSPs are achieved by protein, Ca2+, and mitochondrial homeostasis. Autophagy presents antigens to PRRs and helps to clean the pathogens. In addition, the induced autophagy can form a negative feedback regulation of PRRs-mediated inflammation in cell/disease-specific manner to maintain homeostasis and prevent excessive inflammation. Understanding the interaction between PRRs and autophagy in a specific disease will promote drug development for immunotherapy. Here, we focus on the interactions between PRRs and autophagy and how they affect the inflammatory response.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofAutophagy Regulation of Innate Immunity-
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology ; v. 1209-
dc.subjectPRRs-
dc.subjectAutophagy-
dc.subjectTLRs-
dc.subjectNLRs-
dc.subjectcGAS-STING-
dc.titleThe Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation-
dc.typeBook_Chapter-
dc.identifier.emailWang, PH: pei-hui.wang@connect.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-981-15-0606-2_6-
dc.identifier.pmid31728866-
dc.identifier.scopuseid_2-s2.0-85075038592-
dc.identifier.hkuros315779-
dc.identifier.volume1209-
dc.identifier.spage79-
dc.identifier.epage108-
dc.identifier.eissn2214-8019-
dc.identifier.isiWOS:000514092900006-
dc.publisher.placeSingapore-
dc.identifier.issnl0065-2598-

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