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Article: Reduction of anterior cingulate in adults with urban violence-related PTSD

TitleReduction of anterior cingulate in adults with urban violence-related PTSD
Authors
KeywordsAnterior cingulated
Limbic system
Posttraumatic stress disorder
Brain volume
Issue Date2014
Citation
Journal of Affective Disorders, 2014, v. 168, p. 13-20 How to Cite?
AbstractBackground To evaluate differences in limbic structure volume of subjects exposed to urban violence during adulthood, between those who developed posttraumatic stress disorder (with PTSD) and resilient matched controls (without PTSD). Methods Limbic volumetric measures of 32 subjects with PTSD and 32 subjects without PTSD who underwent brain MRI were analyzed in an epidemiological study in the city of Sao Paulo. The hippocampus, amygdala, cingulate, and parahipocampal gyri volumes were estimated using FreeSurfer software. We also investigated the association between limbic volumetric measurements, symptoḿs severity, and early life stress history (measure by Early Trauma Inventory - ETI). Results Subjects with PTSD presented reduced volume of the right rostral part of the anterior cingulate, compared to subjects without PTSD, after controlling for intracranial volume, ETI, and depressive symptoms. Subjects with PTSD presented larger bilateral hippocampus and right amygdala, but secondary to the higher ETI. In PTSD group there was a positive correlation between ETI with bilateral hippocampus, bilateral amygdala, and left parahippocampus. Limitations First, the cross-sectional study design precludes causal interpretation of limbic structure reduction in PTSD, consequence of PTSD, or other life events. Finally, since the sample size was not sufficiently large, we could not observe whether or not limbic structure volume could be related to the type of trauma. Conclusions The present study provides evidence of a reduced anterior cingulate volume in subjects with PTSD than in resilient subjects exposed to urban violence. Enlargement of hippocampus and amygdala volume was observed in subjects with PTSD, however secondary to early trauma experience. © 2014 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/288634
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBaldaçara, Leonardo-
dc.contributor.authorZugman, André-
dc.contributor.authorAraújo, Célia-
dc.contributor.authorCogo-Moreira, Hugo-
dc.contributor.authorLacerda, Acioly Luiz Tavares-
dc.contributor.authorSchoedl, Aline-
dc.contributor.authorPupo, Mariana-
dc.contributor.authorMello, Marcelo Feijo-
dc.contributor.authorAndreoli, Sergio B.-
dc.contributor.authorDe Jesus Mari, Jair-
dc.contributor.authorBressan, Rodrigo Affonseca-
dc.contributor.authorJackowski, Andrea Parolin-
dc.date.accessioned2020-10-12T08:05:28Z-
dc.date.available2020-10-12T08:05:28Z-
dc.date.issued2014-
dc.identifier.citationJournal of Affective Disorders, 2014, v. 168, p. 13-20-
dc.identifier.issn0165-0327-
dc.identifier.urihttp://hdl.handle.net/10722/288634-
dc.description.abstractBackground To evaluate differences in limbic structure volume of subjects exposed to urban violence during adulthood, between those who developed posttraumatic stress disorder (with PTSD) and resilient matched controls (without PTSD). Methods Limbic volumetric measures of 32 subjects with PTSD and 32 subjects without PTSD who underwent brain MRI were analyzed in an epidemiological study in the city of Sao Paulo. The hippocampus, amygdala, cingulate, and parahipocampal gyri volumes were estimated using FreeSurfer software. We also investigated the association between limbic volumetric measurements, symptoḿs severity, and early life stress history (measure by Early Trauma Inventory - ETI). Results Subjects with PTSD presented reduced volume of the right rostral part of the anterior cingulate, compared to subjects without PTSD, after controlling for intracranial volume, ETI, and depressive symptoms. Subjects with PTSD presented larger bilateral hippocampus and right amygdala, but secondary to the higher ETI. In PTSD group there was a positive correlation between ETI with bilateral hippocampus, bilateral amygdala, and left parahippocampus. Limitations First, the cross-sectional study design precludes causal interpretation of limbic structure reduction in PTSD, consequence of PTSD, or other life events. Finally, since the sample size was not sufficiently large, we could not observe whether or not limbic structure volume could be related to the type of trauma. Conclusions The present study provides evidence of a reduced anterior cingulate volume in subjects with PTSD than in resilient subjects exposed to urban violence. Enlargement of hippocampus and amygdala volume was observed in subjects with PTSD, however secondary to early trauma experience. © 2014 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofJournal of Affective Disorders-
dc.subjectAnterior cingulated-
dc.subjectLimbic system-
dc.subjectPosttraumatic stress disorder-
dc.subjectBrain volume-
dc.titleReduction of anterior cingulate in adults with urban violence-related PTSD-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jad.2014.06.036-
dc.identifier.pmid25033473-
dc.identifier.scopuseid_2-s2.0-84904536902-
dc.identifier.volume168-
dc.identifier.spage13-
dc.identifier.epage20-
dc.identifier.eissn1573-2517-
dc.identifier.isiWOS:000341483100003-
dc.identifier.issnl0165-0327-

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