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Article: Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012
Title | Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012 |
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Authors | |
Keywords | Outbreak Vietnam Enterovirus 71 Phylogenetics C4 subgenogroup |
Issue Date | 2016 |
Citation | Virology, 2016, v. 495, p. 1-9 How to Cite? |
Abstract | © 2016 The Authors. Background: Enterovirus 71 subgenogroup C4 caused the largest outbreak of Hand, Foot and Mouth Disease (HFMD) in Vietnam during 2011-2012, resulting in over 200,000 hospitalisations and 207 fatalities. Methods: A total of 1917 samples with adequate volume for RT-PCR analysis were collected from patients hospitalised with HFMD throughout Vietnam and 637 were positive for EV71. VP1 gene (n=87) and complete genome (n=9) sequencing was performed. Maximum-likelihood phylogenetic analysis was performed to characterise the B5, C4 and C5 strains detected. Results: Sequence analyses revealed that the dominant subgenogroup associated with the 2012 outbreak was C4, with B5 and C5 strains representing a small proportion of these cases. Conclusions: Numerous countries in the region including Malaysia, Taiwan and China have a large influence on strain diversity in Vietnam and understanding the transmission of EV71 throughout Southeast Asia is vital to inform preventative public health measures and vaccine development efforts. |
Persistent Identifier | http://hdl.handle.net/10722/288701 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.838 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Donato, Celeste | - |
dc.contributor.author | Hoi, Le Thi | - |
dc.contributor.author | Hoa, Nguyen Thi | - |
dc.contributor.author | Hoa, Tran Mai | - |
dc.contributor.author | Van Duyet, Le | - |
dc.contributor.author | Dieu Ngan, Ta Thi | - |
dc.contributor.author | Van Kinh, Nguyen | - |
dc.contributor.author | Vu Trung, Nguyen | - |
dc.contributor.author | Vijaykrishna, Dhanasekaran | - |
dc.date.accessioned | 2020-10-12T08:05:39Z | - |
dc.date.available | 2020-10-12T08:05:39Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Virology, 2016, v. 495, p. 1-9 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288701 | - |
dc.description.abstract | © 2016 The Authors. Background: Enterovirus 71 subgenogroup C4 caused the largest outbreak of Hand, Foot and Mouth Disease (HFMD) in Vietnam during 2011-2012, resulting in over 200,000 hospitalisations and 207 fatalities. Methods: A total of 1917 samples with adequate volume for RT-PCR analysis were collected from patients hospitalised with HFMD throughout Vietnam and 637 were positive for EV71. VP1 gene (n=87) and complete genome (n=9) sequencing was performed. Maximum-likelihood phylogenetic analysis was performed to characterise the B5, C4 and C5 strains detected. Results: Sequence analyses revealed that the dominant subgenogroup associated with the 2012 outbreak was C4, with B5 and C5 strains representing a small proportion of these cases. Conclusions: Numerous countries in the region including Malaysia, Taiwan and China have a large influence on strain diversity in Vietnam and understanding the transmission of EV71 throughout Southeast Asia is vital to inform preventative public health measures and vaccine development efforts. | - |
dc.language | eng | - |
dc.relation.ispartof | Virology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Outbreak | - |
dc.subject | Vietnam | - |
dc.subject | Enterovirus 71 | - |
dc.subject | Phylogenetics | - |
dc.subject | C4 subgenogroup | - |
dc.title | Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012 | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.virol.2016.04.026 | - |
dc.identifier.pmid | 27148893 | - |
dc.identifier.scopus | eid_2-s2.0-84966378367 | - |
dc.identifier.volume | 495 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 9 | - |
dc.identifier.eissn | 1096-0341 | - |
dc.identifier.isi | WOS:000378659900001 | - |
dc.identifier.issnl | 0042-6822 | - |