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Article: Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment

TitleSoluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment
Authors
KeywordsOxylipins
Small vessel disease
Linoleic acid
Soluble epoxide hydrolase
Vascular cognitive impairment
Issue Date2019
Citation
Translational Stroke Research, 2019, v. 10, n. 5, p. 522-533 How to Cite?
Abstract© 2018, Springer Science+Business Media, LLC, part of Springer Nature. White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides into their less active corresponding diol species. Under the hypothesis that the activity of sEH might be associated with subcortical ischemic vascular disease and vascular cognitive impairment, this study aimed to compare the relative abundance of sEH substrates and products in peripheral blood between patients with extensive WMH (discovered due to transient ischemic attack; n = 29) and healthy elderly with minimal WMH (n = 25). The concentration of 12,13-DiHOME (a sEH-derived linoleic acid metabolite), and the ratio of 12,13-DiHOME to its sEH substrate, 12,13-EpOME, were elevated in the extensive WMH group (F1,53 = 5.9, p = 0.019), as was the 9,10-DiHOME/9,10-EpOME ratio (F1,53 = 5.4, p = 0.024). The 12,13-DiHOME/12,13-EpOME ratio was associated with poorer performance on a composite score derived from tests of psychomotor processing speed, attention, and executive function (β = − 0.473, p = 0.001, adjusted r2 = 0.213), but not with a composite verbal memory score. In a mediation model, periventricular WMH (but not deep WMH), explained 37% of the effect of the 12,13-DiHOME/12,13-EpOME ratio on the speed/attention/executive function composite score (indirect effect = − 0.50, 95% bootstrap confidence interval [− 0.99, − 0.17] Z-score units). Serum oxylipin changes consistent with higher sEH activity were markers of vascular cognitive impairment, and this association was partly explained by injury to the periventricular subcortical white matter.
Persistent Identifierhttp://hdl.handle.net/10722/288760
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.595
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, Di-
dc.contributor.authorHennebelle, Marie-
dc.contributor.authorSahlas, Demetrios J.-
dc.contributor.authorRamirez, Joel-
dc.contributor.authorGao, Fuqiang-
dc.contributor.authorMasellis, Mario-
dc.contributor.authorCogo-Moreira, Hugo-
dc.contributor.authorSwartz, Richard H.-
dc.contributor.authorHerrmann, Nathan-
dc.contributor.authorChan, Pak Cheung-
dc.contributor.authorPettersen, Jacqueline A.-
dc.contributor.authorStuss, Donald T.-
dc.contributor.authorBlack, Sandra E.-
dc.contributor.authorTaha, Ameer Y.-
dc.contributor.authorSwardfager, Walter-
dc.date.accessioned2020-10-12T08:05:48Z-
dc.date.available2020-10-12T08:05:48Z-
dc.date.issued2019-
dc.identifier.citationTranslational Stroke Research, 2019, v. 10, n. 5, p. 522-533-
dc.identifier.issn1868-4483-
dc.identifier.urihttp://hdl.handle.net/10722/288760-
dc.description.abstract© 2018, Springer Science+Business Media, LLC, part of Springer Nature. White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides into their less active corresponding diol species. Under the hypothesis that the activity of sEH might be associated with subcortical ischemic vascular disease and vascular cognitive impairment, this study aimed to compare the relative abundance of sEH substrates and products in peripheral blood between patients with extensive WMH (discovered due to transient ischemic attack; n = 29) and healthy elderly with minimal WMH (n = 25). The concentration of 12,13-DiHOME (a sEH-derived linoleic acid metabolite), and the ratio of 12,13-DiHOME to its sEH substrate, 12,13-EpOME, were elevated in the extensive WMH group (F1,53 = 5.9, p = 0.019), as was the 9,10-DiHOME/9,10-EpOME ratio (F1,53 = 5.4, p = 0.024). The 12,13-DiHOME/12,13-EpOME ratio was associated with poorer performance on a composite score derived from tests of psychomotor processing speed, attention, and executive function (β = − 0.473, p = 0.001, adjusted r2 = 0.213), but not with a composite verbal memory score. In a mediation model, periventricular WMH (but not deep WMH), explained 37% of the effect of the 12,13-DiHOME/12,13-EpOME ratio on the speed/attention/executive function composite score (indirect effect = − 0.50, 95% bootstrap confidence interval [− 0.99, − 0.17] Z-score units). Serum oxylipin changes consistent with higher sEH activity were markers of vascular cognitive impairment, and this association was partly explained by injury to the periventricular subcortical white matter.-
dc.languageeng-
dc.relation.ispartofTranslational Stroke Research-
dc.subjectOxylipins-
dc.subjectSmall vessel disease-
dc.subjectLinoleic acid-
dc.subjectSoluble epoxide hydrolase-
dc.subjectVascular cognitive impairment-
dc.titleSoluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12975-018-0672-5-
dc.identifier.pmid30443886-
dc.identifier.scopuseid_2-s2.0-85056664452-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.spage522-
dc.identifier.epage533-
dc.identifier.eissn1868-601X-
dc.identifier.isiWOS:000484926800008-
dc.identifier.issnl1868-4483-

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