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- Publisher Website: 10.1111/irv.12725
- Scopus: eid_2-s2.0-85079367050
- PMID: 32045100
- WOS: WOS:000512456200001
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Article: A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions
Title | A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions |
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Authors | |
Keywords | baloxavir marboxil influenza viruses pyrosequencing I38T antiviral resistance |
Issue Date | 2020 |
Citation | Influenza and Other Respiratory Viruses, 2020, v. 14, n. 4, p. 460-464 How to Cite? |
Abstract | © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we describe a genotypic pyrosequencing method that can be used to rapidly screen circulating influenza A and B viruses for substitutions in the PA/I38 codon and to quantify mixed viral populations. This method is suitable for surveillance of baloxavir susceptibility and to analyse samples from hospitalised patients undergoing baloxavir treatment to aid in clinical decision making. |
Persistent Identifier | http://hdl.handle.net/10722/288791 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.485 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Koszalka, Paulina | - |
dc.contributor.author | Farrukee, Rubaiyea | - |
dc.contributor.author | Mifsud, Edin | - |
dc.contributor.author | Vijaykrishna, Dhanasekaran | - |
dc.contributor.author | Hurt, Aeron C. | - |
dc.date.accessioned | 2020-10-12T08:05:53Z | - |
dc.date.available | 2020-10-12T08:05:53Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Influenza and Other Respiratory Viruses, 2020, v. 14, n. 4, p. 460-464 | - |
dc.identifier.issn | 1750-2640 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288791 | - |
dc.description.abstract | © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we describe a genotypic pyrosequencing method that can be used to rapidly screen circulating influenza A and B viruses for substitutions in the PA/I38 codon and to quantify mixed viral populations. This method is suitable for surveillance of baloxavir susceptibility and to analyse samples from hospitalised patients undergoing baloxavir treatment to aid in clinical decision making. | - |
dc.language | eng | - |
dc.relation.ispartof | Influenza and Other Respiratory Viruses | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | baloxavir marboxil | - |
dc.subject | influenza viruses | - |
dc.subject | pyrosequencing | - |
dc.subject | I38T | - |
dc.subject | antiviral resistance | - |
dc.title | A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/irv.12725 | - |
dc.identifier.pmid | 32045100 | - |
dc.identifier.pmcid | PMC7298287 | - |
dc.identifier.scopus | eid_2-s2.0-85079367050 | - |
dc.identifier.hkuros | 317452 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 460 | - |
dc.identifier.epage | 464 | - |
dc.identifier.eissn | 1750-2659 | - |
dc.identifier.isi | WOS:000512456200001 | - |
dc.identifier.issnl | 1750-2640 | - |