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- Publisher Website: 10.1111/acps.12453
- Scopus: eid_2-s2.0-84953836269
- PMID: 26139469
- WOS: WOS:000368003600004
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Article: Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample
Title | Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample |
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Authors | |
Keywords | Mental disorders Biomarkers Psychopathology Adolescence Childhood |
Issue Date | 2016 |
Citation | Acta Psychiatrica Scandinavica, 2016, v. 133, n. 2, p. 122-132 How to Cite? |
Abstract | © 2016 John Wiley & Sons A/S. Objective: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based study. Psychopathology was assessed using the Child Behaviour Checklist (CBCL). Psychiatric diagnosis was evaluated using the Development and Well-Being Assessment. The following biomarkers were examined in peripheral blood: brain-derived neurotrophic factor, cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, IFN-g, and TNF-α), chemokines (eotaxin/CCL11, IP-10, MCP-1), cytokine receptors (sTNFR1 and sTNFR2), and the oxidative stress marker TBARS. Results: We found significant associations between sTNFR2, eotaxin/CCL11 and CBCL total score, as well as with specific dimensions of psychopathology. There were different patterns of association between these biomarkers and psychological and behavioural symptoms in children with and without a mental disorder. TBARS, IL-6 and MCP-1 were more specific to some clusters of symptoms in children with a psychiatric diagnosis. Conclusion: Our data support the potential use of biomarkers, especially those involved in immune-inflammatory pathways, in investigating neurodevelopmental psychopathology. Their association with different dimensions of symptoms might be of useful when analyzing illness severity and clusters of symptoms within specific disorders. |
Persistent Identifier | http://hdl.handle.net/10722/288842 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 2.615 |
ISI Accession Number ID | |
Errata |
DC Field | Value | Language |
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dc.contributor.author | Cunha, G. R. | - |
dc.contributor.author | Asevedo, E. | - |
dc.contributor.author | Mansur, R. B. | - |
dc.contributor.author | Zugman, A. | - |
dc.contributor.author | Pan, P. M. | - |
dc.contributor.author | Gadelha, A. | - |
dc.contributor.author | Belangero, S. I. | - |
dc.contributor.author | Rizzo, L. B. | - |
dc.contributor.author | Coelho, R. | - |
dc.contributor.author | Stertz, L. | - |
dc.contributor.author | Cogo-Moreira, H. | - |
dc.contributor.author | Grassi-Oliveira, R. | - |
dc.contributor.author | Teixeira, A. L. | - |
dc.contributor.author | Kauer-Sant'Anna, M. | - |
dc.contributor.author | Mari, J. J. | - |
dc.contributor.author | Miguel, E. C. | - |
dc.contributor.author | Bressan, R. A. | - |
dc.contributor.author | Brietzke, E. | - |
dc.date.accessioned | 2020-10-12T08:06:01Z | - |
dc.date.available | 2020-10-12T08:06:01Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Acta Psychiatrica Scandinavica, 2016, v. 133, n. 2, p. 122-132 | - |
dc.identifier.issn | 0001-690X | - |
dc.identifier.uri | http://hdl.handle.net/10722/288842 | - |
dc.description.abstract | © 2016 John Wiley & Sons A/S. Objective: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based study. Psychopathology was assessed using the Child Behaviour Checklist (CBCL). Psychiatric diagnosis was evaluated using the Development and Well-Being Assessment. The following biomarkers were examined in peripheral blood: brain-derived neurotrophic factor, cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, IFN-g, and TNF-α), chemokines (eotaxin/CCL11, IP-10, MCP-1), cytokine receptors (sTNFR1 and sTNFR2), and the oxidative stress marker TBARS. Results: We found significant associations between sTNFR2, eotaxin/CCL11 and CBCL total score, as well as with specific dimensions of psychopathology. There were different patterns of association between these biomarkers and psychological and behavioural symptoms in children with and without a mental disorder. TBARS, IL-6 and MCP-1 were more specific to some clusters of symptoms in children with a psychiatric diagnosis. Conclusion: Our data support the potential use of biomarkers, especially those involved in immune-inflammatory pathways, in investigating neurodevelopmental psychopathology. Their association with different dimensions of symptoms might be of useful when analyzing illness severity and clusters of symptoms within specific disorders. | - |
dc.language | eng | - |
dc.relation.ispartof | Acta Psychiatrica Scandinavica | - |
dc.subject | Mental disorders | - |
dc.subject | Biomarkers | - |
dc.subject | Psychopathology | - |
dc.subject | Adolescence | - |
dc.subject | Childhood | - |
dc.title | Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/acps.12453 | - |
dc.identifier.pmid | 26139469 | - |
dc.identifier.scopus | eid_2-s2.0-84953836269 | - |
dc.identifier.volume | 133 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 122 | - |
dc.identifier.epage | 132 | - |
dc.identifier.eissn | 1600-0447 | - |
dc.identifier.isi | WOS:000368003600004 | - |
dc.relation.erratum | doi:10.1111/acps.12646 | - |
dc.identifier.issnl | 0001-690X | - |