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- Publisher Website: 10.1093/infdis/jix500
- Scopus: eid_2-s2.0-85038641673
- PMID: 29029128
- WOS: WOS:000417960300008
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Article: Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam
Title | Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam |
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Authors | |
Keywords | Vietnam Hand foot and mouth disease Enterovirus A71 Phylogenetics |
Issue Date | 2017 |
Citation | Journal of Infectious Diseases, 2017, v. 216, n. 11, p. 1371-1379 How to Cite? |
Abstract | © 2017 The Author. Background. Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephaliThis in children across the Asia-Pacifc region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. Te relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods. A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to coestimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network. Results. Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specifc Asian countries representing genogroup-specifc sources of EV-A71 diversity. Conclusion. This study highlights a persistent transmission network of EV-A71, with specifc Asian countries seeding other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance and detailed genetic and antigenic characterization. |
Persistent Identifier | http://hdl.handle.net/10722/288897 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Thao, Nguyen Thi Thanh | - |
dc.contributor.author | Donato, Celeste | - |
dc.contributor.author | Trang, Vu Thi Huyen | - |
dc.contributor.author | Kien, Nguyen Trung | - |
dc.contributor.author | Trang, Pham Mai Thuy | - |
dc.contributor.author | Khanh, Tran Quoc | - |
dc.contributor.author | Nguyet, Dang Thi | - |
dc.contributor.author | Sessions, October M. | - |
dc.contributor.author | Cuong, Hoang Quoc | - |
dc.contributor.author | Lan, Phan Trong | - |
dc.contributor.author | Huong, Vu Thi Que | - |
dc.contributor.author | Rogier Van Doorn, H. | - |
dc.contributor.author | Vijaykrishna, Dhanasekaran | - |
dc.date.accessioned | 2020-10-12T08:06:09Z | - |
dc.date.available | 2020-10-12T08:06:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2017, v. 216, n. 11, p. 1371-1379 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288897 | - |
dc.description.abstract | © 2017 The Author. Background. Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and viral encephaliThis in children across the Asia-Pacifc region, including in Vietnam, which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5, and B5) concurrently circulate in the region with a large variation in epidemic severity. Te relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods. A total of 752 VP1 gene sequences were analyzed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013, along with epidemiological metadata. Globally representative VP1 gene datasets of subgenogroups were used to coestimate time-resolved phylogenies and relative genetic diversity to infer virus origins and regional transmission network. Results. Despite frequent virus migration between countries, the highest genetic diversity of individual subgenogroups was maintained independently for several years in specifc Asian countries representing genogroup-specifc sources of EV-A71 diversity. Conclusion. This study highlights a persistent transmission network of EV-A71, with specifc Asian countries seeding other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance and detailed genetic and antigenic characterization. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.subject | Vietnam | - |
dc.subject | Hand foot and mouth disease | - |
dc.subject | Enterovirus A71 | - |
dc.subject | Phylogenetics | - |
dc.title | Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/infdis/jix500 | - |
dc.identifier.pmid | 29029128 | - |
dc.identifier.pmcid | PMC5853389 | - |
dc.identifier.scopus | eid_2-s2.0-85038641673 | - |
dc.identifier.volume | 216 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1371 | - |
dc.identifier.epage | 1379 | - |
dc.identifier.eissn | 1537-6613 | - |
dc.identifier.isi | WOS:000417960300008 | - |
dc.identifier.issnl | 0022-1899 | - |