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Article: Factors associated with fatality due to avian influenza A(H7N9) infection in China

TitleFactors associated with fatality due to avian influenza A(H7N9) infection in China
Authors
Keywordsinfluenza
H7N9
zoonotic infection
risk factors
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2020, v. 71 n. 1, p. 128-132 How to Cite?
AbstractBackground The high case fatality rate of influenza A(H7N9)-infected patients has been a major clinical concern. Methods To identify the common causes of death due to H7N9 as well as identify risk factors associated with the high inpatient mortality, we retrospectively collected clinical treatment information from 350 hospitalized human cases of H7N9 virus in mainland China during 2013–2017, of which 109 (31.1%) had died, and systematically analyzed the patients’ clinical characteristics and risk factors for death. Results The median age at time of infection was 57 years, whereas the median age at time of death was 61 years, significantly older than those who survived. In contrast to previous studies, we found nosocomial infections comprising Acinetobacter baumannii and Klebsiella most commonly associated with secondary bacterial infections, which was likely due to the high utilization of supportive therapies, including mechanical ventilation (52.6%), extracorporeal membrane oxygenation (14%), continuous renal replacement therapy (19.1%), and artificial liver therapy (9.7%). Age, time from illness onset to antiviral therapy initiation, and secondary bacterial infection were independent risk factors for death. Age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death. Conclusions Death among H7N9 virus–infected patients occurred rapidly after hospital admission, especially among older patients, followed by severe hypoxemia and multisystem organ failure. Our results show that early neuraminidase-inhibitor therapy and reduction of secondary bacterial infections can help reduce mortality. Characterization of 350 hospitalized avian influenza A(H7N9)-infected patients in China shows that age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death.
Persistent Identifierhttp://hdl.handle.net/10722/288963
ISSN
2019 Impact Factor: 8.313
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZheng, S-
dc.contributor.authorZou, Q-
dc.contributor.authorWang, X-
dc.contributor.authorBao, J-
dc.contributor.authorYu, F-
dc.contributor.authorGuo, F-
dc.contributor.authorLiu, P-
dc.contributor.authorShen, Y-
dc.contributor.authorWang, Y-
dc.contributor.authorYang, S-
dc.contributor.authorWu, W-
dc.contributor.authorSheng, J-
dc.contributor.authorDhanasekaran, V-
dc.contributor.authorGao, H-
dc.contributor.authorChen, Y-
dc.date.accessioned2020-10-12T08:06:19Z-
dc.date.available2020-10-12T08:06:19Z-
dc.date.issued2020-
dc.identifier.citationClinical Infectious Diseases, 2020, v. 71 n. 1, p. 128-132-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/288963-
dc.description.abstractBackground The high case fatality rate of influenza A(H7N9)-infected patients has been a major clinical concern. Methods To identify the common causes of death due to H7N9 as well as identify risk factors associated with the high inpatient mortality, we retrospectively collected clinical treatment information from 350 hospitalized human cases of H7N9 virus in mainland China during 2013–2017, of which 109 (31.1%) had died, and systematically analyzed the patients’ clinical characteristics and risk factors for death. Results The median age at time of infection was 57 years, whereas the median age at time of death was 61 years, significantly older than those who survived. In contrast to previous studies, we found nosocomial infections comprising Acinetobacter baumannii and Klebsiella most commonly associated with secondary bacterial infections, which was likely due to the high utilization of supportive therapies, including mechanical ventilation (52.6%), extracorporeal membrane oxygenation (14%), continuous renal replacement therapy (19.1%), and artificial liver therapy (9.7%). Age, time from illness onset to antiviral therapy initiation, and secondary bacterial infection were independent risk factors for death. Age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death. Conclusions Death among H7N9 virus–infected patients occurred rapidly after hospital admission, especially among older patients, followed by severe hypoxemia and multisystem organ failure. Our results show that early neuraminidase-inhibitor therapy and reduction of secondary bacterial infections can help reduce mortality. Characterization of 350 hospitalized avian influenza A(H7N9)-infected patients in China shows that age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/-
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version Clinical Infectious Diseases, 2020, v. 71 n. 1, p. 128-132 is available online at: https://academic.oup.com/cid/article-abstract/71/1/128/5550614?redirectedFrom=fulltext-
dc.subjectinfluenza-
dc.subjectH7N9-
dc.subjectzoonotic infection-
dc.subjectrisk factors-
dc.titleFactors associated with fatality due to avian influenza A(H7N9) infection in China-
dc.typeArticle-
dc.identifier.emailDhanasekaran, V: veej@hku.hk-
dc.identifier.authorityDhanasekaran, V=rp02721-
dc.description.naturepostprint-
dc.identifier.doi10.1093/cid/ciz779-
dc.identifier.pmid31418813-
dc.identifier.scopuseid_2-s2.0-85073827439-
dc.identifier.hkuros317632-
dc.identifier.volume71-
dc.identifier.issue1-
dc.identifier.spage128-
dc.identifier.epage132-
dc.identifier.eissn1537-6591-
dc.identifier.isiWOS:000551523900022-
dc.publisher.placeUnited States-
dc.identifier.issnl1058-4838-

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