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- Publisher Website: 10.1111/j.1467-789X.2011.00956.x
- Scopus: eid_2-s2.0-84865038106
- PMID: 22133012
- WOS: WOS:000302864000004
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Article: Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: Markers and effect of lifestyle intervention
Title | Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: Markers and effect of lifestyle intervention |
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Authors | |
Keywords | Oxidative stress Inflammation Endothelial dysfunction Childhood obesity |
Issue Date | 2012 |
Citation | Obesity Reviews, 2012, v. 13, n. 5, p. 441-455 How to Cite? |
Abstract | With an increasing prevalence, pediatric obesity is often a prelude to adulthood obesity, and represents a major public health issue. Comorbidities are very common and severe in obese adults, justifying the search for earlier markers or risk factors for cardiovascular diseases in obese children. Endothelial dysfunction has been found to be present in the early stages of atherosclerosis, and can be non-invasively assessed with widely accepted and well-standardized techniques at the macrocirculation level. Endothelial dysfunction at the microcirculation level is less documented in obese children. Obesity in children has been repeatedly and independently correlated to endothelial dysfunction, inflammation and oxidative stress markers, although the relationship between these factors remains to be investigated. However, this would not only allow substantial improvements in risk stratification, but also provide essential data regarding the evolution of endothelial dysfunction in childhood obesity, especially during puberty when pro-inflammatory and pro-oxidative changes, with relative insulin resistance, occur. Therapeutic strategies such as lifestyle interventions in early childhood obesity appear all the more necessary, optimally including both exercise and diet because of their known effects on inflammatory and oxidative stress markers, potentially reversing endothelial dysfunction. © 2011 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/289016 |
ISSN | 2023 Impact Factor: 8.0 2023 SCImago Journal Rankings: 2.818 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Montero, D. | - |
dc.contributor.author | Walther, G. | - |
dc.contributor.author | Perez-Martin, A. | - |
dc.contributor.author | Roche, E. | - |
dc.contributor.author | Vinet, A. | - |
dc.date.accessioned | 2020-10-12T08:06:28Z | - |
dc.date.available | 2020-10-12T08:06:28Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Obesity Reviews, 2012, v. 13, n. 5, p. 441-455 | - |
dc.identifier.issn | 1467-7881 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289016 | - |
dc.description.abstract | With an increasing prevalence, pediatric obesity is often a prelude to adulthood obesity, and represents a major public health issue. Comorbidities are very common and severe in obese adults, justifying the search for earlier markers or risk factors for cardiovascular diseases in obese children. Endothelial dysfunction has been found to be present in the early stages of atherosclerosis, and can be non-invasively assessed with widely accepted and well-standardized techniques at the macrocirculation level. Endothelial dysfunction at the microcirculation level is less documented in obese children. Obesity in children has been repeatedly and independently correlated to endothelial dysfunction, inflammation and oxidative stress markers, although the relationship between these factors remains to be investigated. However, this would not only allow substantial improvements in risk stratification, but also provide essential data regarding the evolution of endothelial dysfunction in childhood obesity, especially during puberty when pro-inflammatory and pro-oxidative changes, with relative insulin resistance, occur. Therapeutic strategies such as lifestyle interventions in early childhood obesity appear all the more necessary, optimally including both exercise and diet because of their known effects on inflammatory and oxidative stress markers, potentially reversing endothelial dysfunction. © 2011 The Authors. | - |
dc.language | eng | - |
dc.relation.ispartof | Obesity Reviews | - |
dc.subject | Oxidative stress | - |
dc.subject | Inflammation | - |
dc.subject | Endothelial dysfunction | - |
dc.subject | Childhood obesity | - |
dc.title | Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: Markers and effect of lifestyle intervention | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1467-789X.2011.00956.x | - |
dc.identifier.pmid | 22133012 | - |
dc.identifier.scopus | eid_2-s2.0-84865038106 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 441 | - |
dc.identifier.epage | 455 | - |
dc.identifier.eissn | 1467-789X | - |
dc.identifier.isi | WOS:000302864000004 | - |
dc.identifier.issnl | 1467-7881 | - |