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Article: Skeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid

TitleSkeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid
Authors
Keywordsanimal experiment
animal model
bone defect
bone density
bone remodeling
Issue Date2019
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
BioMed Research International, 2019, v. 2019, p. article no. 5138175 How to Cite?
AbstractBisphosphonates (BPs) have been extensively used for management of bone diseases with pathologically high resorption. Despite the great clinical benefits, a severe complication known as medication-related osteonecrosis of the jaw (MRONJ) has been reported. It is found that most of the reported MRONJ cases were limited in the jawbones/craniofacial bones instead of long bones. The present study aims to investigate the differential bone response to surgical procedures between jawbones and long bones exposed to BPs. Forty-eight skeletal mature Sprague Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla, and a bone defect creation on the femur. After surgical procedures, ZA or saline treatment were continued until sacrifice at week 2, week 4, and week 8, post-operatively. The samples were subjected to micro-computerized tomography (micro-CT) and histological assessment. Osteonecrosis was only found in jawbones in ZA-treated rats. ZA-treated rats showed significantly higher bone mineral density with greater bone volume in all surgical sites than that in the controls. The length of exposure of ZA did not seem to affect trabecular microstructure, and it only showed higher bone volume and BMD with longer healing time which is expected in the healing process.
Persistent Identifierhttp://hdl.handle.net/10722/289116
ISSN
2019 Impact Factor: 2.276
2015 SCImago Journal Rankings: 0.725
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, JY-
dc.contributor.authorHuo, L-
dc.contributor.authorYu, RQ-
dc.contributor.authorRao, NJ-
dc.contributor.authorLu, W-
dc.contributor.authorZheng, L-
dc.date.accessioned2020-10-22T08:08:03Z-
dc.date.available2020-10-22T08:08:03Z-
dc.date.issued2019-
dc.identifier.citationBioMed Research International, 2019, v. 2019, p. article no. 5138175-
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/10722/289116-
dc.description.abstractBisphosphonates (BPs) have been extensively used for management of bone diseases with pathologically high resorption. Despite the great clinical benefits, a severe complication known as medication-related osteonecrosis of the jaw (MRONJ) has been reported. It is found that most of the reported MRONJ cases were limited in the jawbones/craniofacial bones instead of long bones. The present study aims to investigate the differential bone response to surgical procedures between jawbones and long bones exposed to BPs. Forty-eight skeletal mature Sprague Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla, and a bone defect creation on the femur. After surgical procedures, ZA or saline treatment were continued until sacrifice at week 2, week 4, and week 8, post-operatively. The samples were subjected to micro-computerized tomography (micro-CT) and histological assessment. Osteonecrosis was only found in jawbones in ZA-treated rats. ZA-treated rats showed significantly higher bone mineral density with greater bone volume in all surgical sites than that in the controls. The length of exposure of ZA did not seem to affect trabecular microstructure, and it only showed higher bone volume and BMD with longer healing time which is expected in the healing process.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html-
dc.relation.ispartofBioMed Research International-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectbone defect-
dc.subjectbone density-
dc.subjectbone remodeling-
dc.titleSkeletal Site-Specific Response of Jawbones and Long Bones to Surgical Interventions in Rats Treated with Zoledronic Acid-
dc.typeArticle-
dc.identifier.emailLu, W: wwlu@hku.hk-
dc.identifier.emailZheng, L: lwzheng@hkucc.hku.hk-
dc.identifier.authorityLu, W=rp00411-
dc.identifier.authorityZheng, L=rp01411-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2019/5138175-
dc.identifier.pmid31930124-
dc.identifier.pmcidPMC6942746-
dc.identifier.scopuseid_2-s2.0-85077735090-
dc.identifier.hkuros317146-
dc.identifier.volume2019-
dc.identifier.spagearticle no. 5138175-
dc.identifier.epagearticle no. 5138175-
dc.identifier.isiWOS:000505936100004-
dc.publisher.placeUnited States-
dc.identifier.issnl2314-6133-

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