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Article: Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities

TitleLarge-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities
Authors
Keywordstick
genome
metagenome
hematophagy
genetic diversity
Issue Date2020
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cell
Citation
Cell, 2020, v. 182 n. 5, p. 1328-1340.e13 How to Cite?
AbstractAmong arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.
Persistent Identifierhttp://hdl.handle.net/10722/289243
ISSN
2020 Impact Factor: 41.582
2020 SCImago Journal Rankings: 26.304
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJia, N-
dc.contributor.authorWang, J-
dc.contributor.authorShi, W-
dc.contributor.authorDu, L-
dc.contributor.authorSun, Y-
dc.contributor.authorZhan, W-
dc.contributor.authorJiang, JF-
dc.contributor.authorWang, Q-
dc.contributor.authorZhang, B-
dc.contributor.authorJi, P-
dc.contributor.authorBell-Sakyi, L-
dc.contributor.authorCui, XM-
dc.contributor.authorYuan, TT-
dc.contributor.authorJiang, BG-
dc.contributor.authorYang, WF-
dc.contributor.authorLam, TTY-
dc.contributor.authorChang, QC-
dc.contributor.authorDing, SJ-
dc.contributor.authorWang, XJ-
dc.contributor.authorZhu, JG-
dc.contributor.authorRuan, XD-
dc.contributor.authorZhao, L-
dc.contributor.authorWei, JT-
dc.contributor.authorYe, RZ-
dc.contributor.authorQue, TC-
dc.contributor.authorDu, CH-
dc.contributor.authorZhou, YH-
dc.contributor.authorCheng, JX-
dc.contributor.authorDai, PF-
dc.contributor.authorGuo, WB-
dc.contributor.authorHan, XH-
dc.contributor.authorHuang, EJ-
dc.contributor.authorLi, LF-
dc.contributor.authorWei, W-
dc.contributor.authorGao, YC-
dc.contributor.authorLiu, JZ-
dc.contributor.authorShao, HZ-
dc.contributor.authorWang, X-
dc.contributor.authorWang, CC-
dc.contributor.authorYang, TC-
dc.contributor.authorHuo, QB-
dc.contributor.authorLi, W-
dc.contributor.authorChen, HY-
dc.contributor.authorChen, SE-
dc.contributor.authorZhou, LG-
dc.contributor.authorNi, XB-
dc.contributor.authorTian, JH-
dc.contributor.authorSheng, Y-
dc.contributor.authorLiu, T-
dc.contributor.authorPan, YS-
dc.contributor.authorXia, LY-
dc.contributor.authorLi, J-
dc.contributor.authorTick Genome and Microbiome Consortium (TIGMIC)-
dc.contributor.authorZhao, F-
dc.contributor.authorCao, WC-
dc.date.accessioned2020-10-22T08:09:54Z-
dc.date.available2020-10-22T08:09:54Z-
dc.date.issued2020-
dc.identifier.citationCell, 2020, v. 182 n. 5, p. 1328-1340.e13-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/289243-
dc.description.abstractAmong arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.-
dc.languageeng-
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cell-
dc.relation.ispartofCell-
dc.subjecttick-
dc.subjectgenome-
dc.subjectmetagenome-
dc.subjecthematophagy-
dc.subjectgenetic diversity-
dc.titleLarge-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities-
dc.typeArticle-
dc.identifier.emailLam, TTY: ttylam@hku.hk-
dc.identifier.authorityLam, TTY=rp01733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cell.2020.07.023-
dc.identifier.pmid32814014-
dc.identifier.scopuseid_2-s2.0-85090008847-
dc.identifier.hkuros316842-
dc.identifier.volume182-
dc.identifier.issue5-
dc.identifier.spage1328-
dc.identifier.epage1340.e13-
dc.identifier.isiWOS:000571442200020-
dc.publisher.placeUnited States-
dc.identifier.issnl0092-8674-

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