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Article: Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

TitleShort-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice
Authors
KeywordsResistance exercise
Neuroinflammation
Alzheimer’s disease
Tau
Amyloid
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jneuroinflammation.com/home/
Citation
Journal of Neuroinflammation, 2020, v. 17 n. 1, p. article no. 4 How to Cite?
AbstractBackground: Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized. Methods: We evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading. Results: Compared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated. Conclusions: Short-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer’s disease.
Persistent Identifierhttp://hdl.handle.net/10722/289246
ISSN
2023 Impact Factor: 9.3
2023 SCImago Journal Rankings: 2.831
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Y-
dc.contributor.authorChu, JMT-
dc.contributor.authorYan, T-
dc.contributor.authorZhang, Y-
dc.contributor.authorChen, Y-
dc.contributor.authorChang, RCC-
dc.contributor.authorWong, GTC-
dc.date.accessioned2020-10-22T08:09:56Z-
dc.date.available2020-10-22T08:09:56Z-
dc.date.issued2020-
dc.identifier.citationJournal of Neuroinflammation, 2020, v. 17 n. 1, p. article no. 4-
dc.identifier.issn1742-2094-
dc.identifier.urihttp://hdl.handle.net/10722/289246-
dc.description.abstractBackground: Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized. Methods: We evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading. Results: Compared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated. Conclusions: Short-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer’s disease.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jneuroinflammation.com/home/-
dc.relation.ispartofJournal of Neuroinflammation-
dc.rightsJournal of Neuroinflammation. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectResistance exercise-
dc.subjectNeuroinflammation-
dc.subjectAlzheimer’s disease-
dc.subjectTau-
dc.subjectAmyloid-
dc.titleShort-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice-
dc.typeArticle-
dc.identifier.emailChu, JMT: jmtchu@hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.authorityChang, RCC=rp00470-
dc.identifier.authorityWong, GTC=rp00523-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12974-019-1653-7-
dc.identifier.pmid31900170-
dc.identifier.pmcidPMC6942350-
dc.identifier.scopuseid_2-s2.0-85077480030-
dc.identifier.hkuros317247-
dc.identifier.volume17-
dc.identifier.issue1-
dc.identifier.spagearticle no. 4-
dc.identifier.epagearticle no. 4-
dc.identifier.isiWOS:000512665200004-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1742-2094-

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