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Article: Statistical profiling of oral cancer and the prediction of outcome

TitleStatistical profiling of oral cancer and the prediction of outcome
Authors
Keywordsoral cancer
oral mucosa
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714
Citation
Journal of Oral Pathology & Medicine, 2021, v. 50 n. 1, p. 39-46 How to Cite?
AbstractBackground: The global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of “high‐risk” patients and appropriately target combination cancer therapies. Methods: A retrospective review of 467 OSCC patients treated over a 19‐year period facilitated detailed clinico‐pathological database analysis and determination of clinical outcome categories based upon time to progressive disease (loco‐regional tumour recurrence and/or distant metastasis), overall death and OSCC‐related death (death directly attributable to OSCC). Odds ratio (OR) and hazard ratio (HR) statistical measures were used to investigate relationships between patient demographics and clinico‐pathological tumour features with clinical outcome. Results: Older age at presentation (P = .002) and a history of previous non–head and neck cancer (P = .010) increased the risk of overall death. OR for progressive disease development (P = .008) and OSCC‐related death (P = .019) was most significant for buccal tumours. HR confirmed advanced‐stage disease increased the risk of progressive disease (P < .001), overall death (P < .001) and OSCC‐related death (P < .001). Positive resection margins were associated with a higher risk of OSCC‐related death (P = .023). Significantly lower risks of progressive disease development (P = .002) and OSCC‐related death (P = .012) were seen in patients undergoing neck dissection, whilst combination chemoradiotherapy reduced HR for overall death (P < .001) and OSCC‐related death (P = .011). Conclusion: Statistical profiling of OSCC clinico‐pathological data identifies significant influences on clinical outcome. This study adds evidence to the hypothesis that buccal SCC displays aggressive tumour behaviour and poor clinical outcome.
Persistent Identifierhttp://hdl.handle.net/10722/289256
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, W-
dc.contributor.authorADEOYE, J-
dc.contributor.authorThomson, P-
dc.contributor.authorChoi, SW-
dc.date.accessioned2020-10-22T08:10:05Z-
dc.date.available2020-10-22T08:10:05Z-
dc.date.issued2021-
dc.identifier.citationJournal of Oral Pathology & Medicine, 2021, v. 50 n. 1, p. 39-46-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/289256-
dc.description.abstractBackground: The global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of “high‐risk” patients and appropriately target combination cancer therapies. Methods: A retrospective review of 467 OSCC patients treated over a 19‐year period facilitated detailed clinico‐pathological database analysis and determination of clinical outcome categories based upon time to progressive disease (loco‐regional tumour recurrence and/or distant metastasis), overall death and OSCC‐related death (death directly attributable to OSCC). Odds ratio (OR) and hazard ratio (HR) statistical measures were used to investigate relationships between patient demographics and clinico‐pathological tumour features with clinical outcome. Results: Older age at presentation (P = .002) and a history of previous non–head and neck cancer (P = .010) increased the risk of overall death. OR for progressive disease development (P = .008) and OSCC‐related death (P = .019) was most significant for buccal tumours. HR confirmed advanced‐stage disease increased the risk of progressive disease (P < .001), overall death (P < .001) and OSCC‐related death (P < .001). Positive resection margins were associated with a higher risk of OSCC‐related death (P = .023). Significantly lower risks of progressive disease development (P = .002) and OSCC‐related death (P = .012) were seen in patients undergoing neck dissection, whilst combination chemoradiotherapy reduced HR for overall death (P < .001) and OSCC‐related death (P = .011). Conclusion: Statistical profiling of OSCC clinico‐pathological data identifies significant influences on clinical outcome. This study adds evidence to the hypothesis that buccal SCC displays aggressive tumour behaviour and poor clinical outcome.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectoral cancer-
dc.subjectoral mucosa-
dc.titleStatistical profiling of oral cancer and the prediction of outcome-
dc.typeArticle-
dc.identifier.emailWang, W: ericawlw@hku.hk-
dc.identifier.emailThomson, P: thomsonp@hku.hk-
dc.identifier.emailChoi, SW: htswchoi@hku.hk-
dc.identifier.authorityThomson, P=rp02327-
dc.identifier.authorityChoi, SW=rp02552-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jop.13110-
dc.identifier.pmid32939835-
dc.identifier.scopuseid_2-s2.0-85091521629-
dc.identifier.hkuros316581-
dc.identifier.volume50-
dc.identifier.issue1-
dc.identifier.spage39-
dc.identifier.epage46-
dc.identifier.isiWOS:000572990700001-
dc.publisher.placeDenmark-
dc.identifier.issnl0904-2512-

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