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Article: Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues

TitleAtomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues
Authors
Keywordsatomic force microscopy
tumor mechanics
cancerous cell
tumor microenvironment
exosome
Issue Date2021
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2021, v. 42, p. 323-339 How to Cite?
AbstractMechanics are intrinsic properties which appears throughout the formation, development, and aging processes of biological systems. Mechanics have been shown to play important roles in regulating the development and metastasis of tumors, and understanding tumor mechanics has emerged as a promising way to reveal the underlying mechanisms guiding tumor behaviors. In particular, tumors are highly complex diseases associated with multifaceted factors, including alterations in cancerous cells, tissues, and organs as well as microenvironmental cues, indicating that investigating tumor mechanics on multiple levels is significantly helpful for comprehensively understanding the effects of mechanics on tumor progression. Recently, diverse techniques have been developed for probing the mechanics of tumors, among which atomic force microscopy (AFM) has appeared as an excellent platform enabling simultaneously characterizing the structures and mechanical properties of living biological systems ranging from individual molecules and cells to tissue samples with unprecedented spatiotemporal resolution, offering novel possibilities for understanding tumor physics and contributing much to the studies of cancer. In this review, we survey the recent progress that has been achieved with the use of AFM for revealing micro/nanoscale mechanics in tumor development and metastasis. Challenges and future progress are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/289265
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.882
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorXi, N-
dc.contributor.authorWang, YC-
dc.contributor.authorLiu, LQ-
dc.date.accessioned2020-10-22T08:10:12Z-
dc.date.available2020-10-22T08:10:12Z-
dc.date.issued2021-
dc.identifier.citationActa Pharmacologica Sinica, 2021, v. 42, p. 323-339-
dc.identifier.issn1671-4083-
dc.identifier.urihttp://hdl.handle.net/10722/289265-
dc.description.abstractMechanics are intrinsic properties which appears throughout the formation, development, and aging processes of biological systems. Mechanics have been shown to play important roles in regulating the development and metastasis of tumors, and understanding tumor mechanics has emerged as a promising way to reveal the underlying mechanisms guiding tumor behaviors. In particular, tumors are highly complex diseases associated with multifaceted factors, including alterations in cancerous cells, tissues, and organs as well as microenvironmental cues, indicating that investigating tumor mechanics on multiple levels is significantly helpful for comprehensively understanding the effects of mechanics on tumor progression. Recently, diverse techniques have been developed for probing the mechanics of tumors, among which atomic force microscopy (AFM) has appeared as an excellent platform enabling simultaneously characterizing the structures and mechanical properties of living biological systems ranging from individual molecules and cells to tissue samples with unprecedented spatiotemporal resolution, offering novel possibilities for understanding tumor physics and contributing much to the studies of cancer. In this review, we survey the recent progress that has been achieved with the use of AFM for revealing micro/nanoscale mechanics in tumor development and metastasis. Challenges and future progress are also discussed.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html-
dc.relation.ispartofActa Pharmacologica Sinica-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectatomic force microscopy-
dc.subjecttumor mechanics-
dc.subjectcancerous cell-
dc.subjecttumor microenvironment-
dc.subjectexosome-
dc.titleAtomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues-
dc.typeArticle-
dc.identifier.emailXi, N: xining@hku.hk-
dc.identifier.authorityXi, N=rp02044-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41401-020-0494-3-
dc.identifier.pmid32807839-
dc.identifier.scopuseid_2-s2.0-85089475569-
dc.identifier.hkuros316336-
dc.identifier.volume42-
dc.identifier.spage323-
dc.identifier.epage339-
dc.identifier.isiWOS:000560282200001-
dc.publisher.placeUnited States-
dc.identifier.issnl1671-4083-

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