File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Antiphospholipid antibodies in patients with lupus nephritis: clinical correlations and associations with long-term outcomes

TitleAntiphospholipid antibodies in patients with lupus nephritis: clinical correlations and associations with long-term outcomes
Authors
KeywordsAntiphospholipid antibodies
lupus nephritis
long term
outcomes
Issue Date2019
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2019, v. 28 n. 12, p. 1460-1467 How to Cite?
AbstractWhether the presence or absence of antiphospholipid antibodies (aPL) in patients with lupus nephritis (LN) is associated with differences in clinical outcomes remains unclear. We reviewed LN patients at a single centre during 2000–2017, and compared the clinical features and long-term outcomes between patients who were seropositive or seronegative for aPL. aPL was detected in 53/149 (35.6%) patients with biopsy-proven LN, and anticardiolipin IgM, anticardiolipin IgG, anti-β2 glycoprotein I and lupus anticoagulant was detected in 18.8%, 18.1%, 10.7% and 8.1%, respectively. Follow-up was 155.8 ± 61.0 months, and was similar between aPL-seropositive and -seronegative patients. aPL seropositivity persisted in 94.3% of patients during remission. aPL-seropositive patients showed inferior patient survival (91% and 85% at 10 and 15 years, respectively, compared to 99% and 95% in aPL-seronegative patients; p = 0.043). Nine (6.0%) patients died during follow-up, including six aPL-seropositive (four thrombotic events and two bleeding complications related to anticoagulation) and three aPL-seronegative patients. aPL seropositivity was associated with more rapid decline in estimated glomerular filtration rate (–1.44 mL/min/year compared to –0.38 mL/min/year in aPL-seronegative patients; p = 0.027) and inferior long-term renal survival (82% and 74% at 10 and 15 years, respectively, compared to 91% and 87% in aPL-seronegative patients; p = 0.034). aPL-seropositive patients also had a higher incidence of thrombotic events and miscarriage (32.1% and 13.2%, respectively, compared to 16.7% and 2.1% in the aPL-seronegative group; p = 0.030 and 0.006). We concluded that aPL seropositivity was associated with inferior long-term patient and renal survival and more frequent thrombotic events and miscarriage in LN patients.
Persistent Identifierhttp://hdl.handle.net/10722/289322
ISSN
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.812
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYap, DYH-
dc.contributor.authorThong, KM-
dc.contributor.authorYung, SY-
dc.contributor.authorTang, C-
dc.contributor.authorMa, BMY-
dc.contributor.authorChan, TM-
dc.date.accessioned2020-10-22T08:11:00Z-
dc.date.available2020-10-22T08:11:00Z-
dc.date.issued2019-
dc.identifier.citationLupus, 2019, v. 28 n. 12, p. 1460-1467-
dc.identifier.issn0961-2033-
dc.identifier.urihttp://hdl.handle.net/10722/289322-
dc.description.abstractWhether the presence or absence of antiphospholipid antibodies (aPL) in patients with lupus nephritis (LN) is associated with differences in clinical outcomes remains unclear. We reviewed LN patients at a single centre during 2000–2017, and compared the clinical features and long-term outcomes between patients who were seropositive or seronegative for aPL. aPL was detected in 53/149 (35.6%) patients with biopsy-proven LN, and anticardiolipin IgM, anticardiolipin IgG, anti-β2 glycoprotein I and lupus anticoagulant was detected in 18.8%, 18.1%, 10.7% and 8.1%, respectively. Follow-up was 155.8 ± 61.0 months, and was similar between aPL-seropositive and -seronegative patients. aPL seropositivity persisted in 94.3% of patients during remission. aPL-seropositive patients showed inferior patient survival (91% and 85% at 10 and 15 years, respectively, compared to 99% and 95% in aPL-seronegative patients; p = 0.043). Nine (6.0%) patients died during follow-up, including six aPL-seropositive (four thrombotic events and two bleeding complications related to anticoagulation) and three aPL-seronegative patients. aPL seropositivity was associated with more rapid decline in estimated glomerular filtration rate (–1.44 mL/min/year compared to –0.38 mL/min/year in aPL-seronegative patients; p = 0.027) and inferior long-term renal survival (82% and 74% at 10 and 15 years, respectively, compared to 91% and 87% in aPL-seronegative patients; p = 0.034). aPL-seropositive patients also had a higher incidence of thrombotic events and miscarriage (32.1% and 13.2%, respectively, compared to 16.7% and 2.1% in the aPL-seronegative group; p = 0.030 and 0.006). We concluded that aPL seropositivity was associated with inferior long-term patient and renal survival and more frequent thrombotic events and miscarriage in LN patients.-
dc.languageeng-
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com-
dc.relation.ispartofLupus-
dc.rightsAuthor(s), Contribution Title, Journal Title (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). DOI: [DOI number].-
dc.subjectAntiphospholipid antibodies-
dc.subjectlupus nephritis-
dc.subjectlong term-
dc.subjectoutcomes-
dc.titleAntiphospholipid antibodies in patients with lupus nephritis: clinical correlations and associations with long-term outcomes-
dc.typeArticle-
dc.identifier.emailYap, DYH: desmondy@hku.hk-
dc.identifier.emailYung, SY: ssyyung@hku.hk-
dc.identifier.emailTang, C: csotang@hkucc.hku.hk-
dc.identifier.emailChan, TM: dtmchan@hkucc.hku.hk-
dc.identifier.authorityYap, DYH=rp01607-
dc.identifier.authorityYung, SY=rp00455-
dc.identifier.authorityChan, TM=rp00394-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0961203319879990-
dc.identifier.pmid31594451-
dc.identifier.scopuseid_2-s2.0-85073184726-
dc.identifier.hkuros315867-
dc.identifier.volume28-
dc.identifier.issue12-
dc.identifier.spage1460-
dc.identifier.epage1467-
dc.identifier.isiWOS:000490003300009-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0961-2033-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats