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- Publisher Website: 10.3390/ijms21197279
- Scopus: eid_2-s2.0-85091891495
- PMID: 33019767
- WOS: WOS:000586646400001
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Article: Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration?
Title | Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration? |
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Authors | |
Keywords | retina vision ocular stress cell damage homeostasis |
Issue Date | 2020 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2020, v. 21 n. 19, p. article no. 7279 How to Cite? |
Abstract | Age-related macular degeneration (AMD) is a leading cause of severe visual loss among the elderly. AMD patients are tormented by progressive central blurring/loss of vision and have limited therapeutic options to date. Drusen accumulation causing retinal pigment epithelial (RPE) cell damage is the hallmark of AMD pathogenesis, in which oxidative stress and inflammation are the well-known molecular mechanisms. However, the underlying mechanisms of how RPE responds when exposed to drusen are still poorly understood. Programmed cell death (PCD) plays an important role in cellular responses to stress and the regulation of homeostasis and diseases. Apart from the classical apoptosis, recent studies also discovered novel PCD pathways such as pyroptosis, necroptosis, and ferroptosis, which may contribute to RPE cell death in AMD. This evidence may yield new treatment targets for AMD. In this review, we summarized and analyzed recent advances on the association between novel PCD and AMD, proposing PCD’s role as a therapeutic new target for future AMD treatment. |
Persistent Identifier | http://hdl.handle.net/10722/289575 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | YANG, M | - |
dc.contributor.author | So, KF | - |
dc.contributor.author | Lam, WC | - |
dc.contributor.author | Lo, ACY | - |
dc.date.accessioned | 2020-10-22T08:14:34Z | - |
dc.date.available | 2020-10-22T08:14:34Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2020, v. 21 n. 19, p. article no. 7279 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289575 | - |
dc.description.abstract | Age-related macular degeneration (AMD) is a leading cause of severe visual loss among the elderly. AMD patients are tormented by progressive central blurring/loss of vision and have limited therapeutic options to date. Drusen accumulation causing retinal pigment epithelial (RPE) cell damage is the hallmark of AMD pathogenesis, in which oxidative stress and inflammation are the well-known molecular mechanisms. However, the underlying mechanisms of how RPE responds when exposed to drusen are still poorly understood. Programmed cell death (PCD) plays an important role in cellular responses to stress and the regulation of homeostasis and diseases. Apart from the classical apoptosis, recent studies also discovered novel PCD pathways such as pyroptosis, necroptosis, and ferroptosis, which may contribute to RPE cell death in AMD. This evidence may yield new treatment targets for AMD. In this review, we summarized and analyzed recent advances on the association between novel PCD and AMD, proposing PCD’s role as a therapeutic new target for future AMD treatment. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | retina | - |
dc.subject | vision | - |
dc.subject | ocular stress | - |
dc.subject | cell damage | - |
dc.subject | homeostasis | - |
dc.title | Novel Programmed Cell Death as Therapeutic Targets in Age-Related Macular Degeneration? | - |
dc.type | Article | - |
dc.identifier.email | So, KF: hrmaskf@hku.hk | - |
dc.identifier.email | Lam, WC: waichlam@hku.hk | - |
dc.identifier.email | Lo, ACY: amylo@hku.hk | - |
dc.identifier.authority | So, KF=rp00329 | - |
dc.identifier.authority | Lam, WC=rp02162 | - |
dc.identifier.authority | Lo, ACY=rp00425 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms21197279 | - |
dc.identifier.pmid | 33019767 | - |
dc.identifier.pmcid | PMC7582463 | - |
dc.identifier.scopus | eid_2-s2.0-85091891495 | - |
dc.identifier.hkuros | 316954 | - |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 19 | - |
dc.identifier.spage | article no. 7279 | - |
dc.identifier.epage | article no. 7279 | - |
dc.identifier.isi | WOS:000586646400001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1422-0067 | - |