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Article: Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model

TitleEffect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model
Authors
Keywordsalveolar bone loss
animal cell
animal experiment
animal model
animal tissue
Issue Date2019
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
BioMed Research International, 2019, v. 2019, p. article no. 1271492 How to Cite?
AbstractObjectives. This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. Materials and Methods. Thirty C57BL/6N mice were randomly divided into three groups (N = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations. Results. Microcomputed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups. Conclusions. Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ.
Persistent Identifierhttp://hdl.handle.net/10722/289646
ISSN
2019 Impact Factor: 2.276
2015 SCImago Journal Rankings: 0.725
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRao, NJ-
dc.contributor.authorYu, RQ-
dc.contributor.authorWang, JY-
dc.contributor.authorHelm, A-
dc.contributor.authorZheng, LW-
dc.date.accessioned2020-10-22T08:15:29Z-
dc.date.available2020-10-22T08:15:29Z-
dc.date.issued2019-
dc.identifier.citationBioMed Research International, 2019, v. 2019, p. article no. 1271492-
dc.identifier.issn2314-6133-
dc.identifier.urihttp://hdl.handle.net/10722/289646-
dc.description.abstractObjectives. This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. Materials and Methods. Thirty C57BL/6N mice were randomly divided into three groups (N = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations. Results. Microcomputed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups. Conclusions. Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html-
dc.relation.ispartofBioMed Research International-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectalveolar bone loss-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.titleEffect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model-
dc.typeArticle-
dc.identifier.emailZheng, LW: lwzheng@hkucc.hku.hk-
dc.identifier.authorityZheng, LW=rp01411-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2019/1271492-
dc.identifier.pmid31662968-
dc.identifier.pmcidPMC6778953-
dc.identifier.scopuseid_2-s2.0-85073164438-
dc.identifier.hkuros317150-
dc.identifier.volume2019-
dc.identifier.spagearticle no. 1271492-
dc.identifier.epagearticle no. 1271492-
dc.identifier.isiWOS:000492942300002-
dc.publisher.placeUnited States-
dc.identifier.issnl2314-6133-

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