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Article: Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials
Title | Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials |
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Authors | |
Keywords | advanced biomaterials all‐aqueous microfluidics cell‐inspiration intracellular organelles liquid–liquid phase separation |
Issue Date | 2020 |
Publisher | Wiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844 |
Citation | Advanced Science, 2020, v. 7 n. 7, p. article no. 1903359 How to Cite? |
Abstract | Living cells have evolved over billions of years to develop structural and functional complexity with numerous intracellular compartments that are formed due to liquid–liquid phase separation (LLPS). Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and replicate the intracellular LLPS. Among them, all‐aqueous emulsions are a minimalistic liquid model that recapitulates the structural and functional features of membraneless organelles and protocells. Here, an emerging all‐aqueous microfluidic technology derived from micrometer‐scaled manipulation of LLPS is presented; the technology enables the state‐of‐art design of advanced biomaterials with exquisite structural proficiency and diversified biological functions. Moreover, a variety of emerging biomedical applications, including encapsulation and delivery of bioactive gradients, fabrication of artificial membraneless organelles, as well as printing and assembly of predesigned cell patterns and living tissues, are inspired by their cellular counterparts. Finally, the challenges and perspectives for further advancing the cell‐inspired all‐aqueous microfluidics toward a more powerful and versatile platform are discussed, particularly regarding new opportunities in multidisciplinary fundamental research and biomedical applications. |
Persistent Identifier | http://hdl.handle.net/10722/289759 |
ISSN | 2023 Impact Factor: 14.3 2023 SCImago Journal Rankings: 3.914 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, Q | - |
dc.contributor.author | Song, Y | - |
dc.contributor.author | Sun, W | - |
dc.contributor.author | Cao, J | - |
dc.contributor.author | Yuan, H | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Sun, Y | - |
dc.contributor.author | Shum, HC | - |
dc.date.accessioned | 2020-10-22T08:17:04Z | - |
dc.date.available | 2020-10-22T08:17:04Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Advanced Science, 2020, v. 7 n. 7, p. article no. 1903359 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289759 | - |
dc.description.abstract | Living cells have evolved over billions of years to develop structural and functional complexity with numerous intracellular compartments that are formed due to liquid–liquid phase separation (LLPS). Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and replicate the intracellular LLPS. Among them, all‐aqueous emulsions are a minimalistic liquid model that recapitulates the structural and functional features of membraneless organelles and protocells. Here, an emerging all‐aqueous microfluidic technology derived from micrometer‐scaled manipulation of LLPS is presented; the technology enables the state‐of‐art design of advanced biomaterials with exquisite structural proficiency and diversified biological functions. Moreover, a variety of emerging biomedical applications, including encapsulation and delivery of bioactive gradients, fabrication of artificial membraneless organelles, as well as printing and assembly of predesigned cell patterns and living tissues, are inspired by their cellular counterparts. Finally, the challenges and perspectives for further advancing the cell‐inspired all‐aqueous microfluidics toward a more powerful and versatile platform are discussed, particularly regarding new opportunities in multidisciplinary fundamental research and biomedical applications. | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844 | - |
dc.relation.ispartof | Advanced Science | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | advanced biomaterials | - |
dc.subject | all‐aqueous microfluidics | - |
dc.subject | cell‐inspiration | - |
dc.subject | intracellular organelles | - |
dc.subject | liquid–liquid phase separation | - |
dc.title | Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials | - |
dc.type | Article | - |
dc.identifier.email | Shum, HC: ashum@hku.hk | - |
dc.identifier.authority | Shum, HC=rp01439 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/advs.201903359 | - |
dc.identifier.pmid | 32274317 | - |
dc.identifier.pmcid | PMC7141073 | - |
dc.identifier.scopus | eid_2-s2.0-85079376088 | - |
dc.identifier.hkuros | 317462 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | article no. 1903359 | - |
dc.identifier.epage | article no. 1903359 | - |
dc.identifier.isi | WOS:000512660700001 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 2198-3844 | - |