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Article: Rapid Multilevel Compartmentalization of Stable All-Aqueous Blastosomes by Interfacial Aqueous-Phase Separation

TitleRapid Multilevel Compartmentalization of Stable All-Aqueous Blastosomes by Interfacial Aqueous-Phase Separation
Authors
Keywordscompartmentalization
aqueous two-phase system
phase separation
nanoparticle surfactant
artificial cells
Issue Date2020
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html
Citation
ACS Nano, 2020, v. 14 n. 9, p. 11215-11224 How to Cite?
AbstractProducing artificial multicellular structures to process multistep cascade reactions and mimic the fundamental aspects of living systems is an outstanding challenge. Highly biocompatible, artificial systems consisting of all-aqueous, compartmentalized multicellular systems have yet to be realized. Here, a rapid multilevel compartmentalization of an all-aqueous system where a 3D sheet of subcolloidosomes encloses a mother colloidosome by interfacial phase separation is demonstrated. These spatially organized multicellular structures are termed “blastosomes” since they are similar to blastula in appearance. The barrier to nanoparticle assembly at the water–water interface is overcome using oppositely charged polyelectrolytes that form a coacervate–nanoparticle–composite network. The conditions required to trigger interfacial phase separation and form blastosomes are quantified in a mapped state diagram. We show a versatile model for constructing artificial multicellular spheroids in all-aqueous systems. The rapid interfacial assembly of charged particles and polyelectrolytes can lock in nonequilibrium shapes of water, which also enables top-down technologies, such as 3D printing and microfluidics, to program flexible compartmentalized structures.
Persistent Identifierhttp://hdl.handle.net/10722/289761
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZHU, S-
dc.contributor.authorForth, J-
dc.contributor.authorXie, G-
dc.contributor.authorCHAO, Y-
dc.contributor.authorTIAN, J-
dc.contributor.authorRussell, TP-
dc.contributor.authorShum, HC-
dc.date.accessioned2020-10-22T08:17:06Z-
dc.date.available2020-10-22T08:17:06Z-
dc.date.issued2020-
dc.identifier.citationACS Nano, 2020, v. 14 n. 9, p. 11215-11224-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/289761-
dc.description.abstractProducing artificial multicellular structures to process multistep cascade reactions and mimic the fundamental aspects of living systems is an outstanding challenge. Highly biocompatible, artificial systems consisting of all-aqueous, compartmentalized multicellular systems have yet to be realized. Here, a rapid multilevel compartmentalization of an all-aqueous system where a 3D sheet of subcolloidosomes encloses a mother colloidosome by interfacial phase separation is demonstrated. These spatially organized multicellular structures are termed “blastosomes” since they are similar to blastula in appearance. The barrier to nanoparticle assembly at the water–water interface is overcome using oppositely charged polyelectrolytes that form a coacervate–nanoparticle–composite network. The conditions required to trigger interfacial phase separation and form blastosomes are quantified in a mapped state diagram. We show a versatile model for constructing artificial multicellular spheroids in all-aqueous systems. The rapid interfacial assembly of charged particles and polyelectrolytes can lock in nonequilibrium shapes of water, which also enables top-down technologies, such as 3D printing and microfluidics, to program flexible compartmentalized structures.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html-
dc.relation.ispartofACS Nano-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectcompartmentalization-
dc.subjectaqueous two-phase system-
dc.subjectphase separation-
dc.subjectnanoparticle surfactant-
dc.subjectartificial cells-
dc.titleRapid Multilevel Compartmentalization of Stable All-Aqueous Blastosomes by Interfacial Aqueous-Phase Separation-
dc.typeArticle-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.0c02923-
dc.identifier.pmid32515582-
dc.identifier.scopuseid_2-s2.0-85091591049-
dc.identifier.hkuros317484-
dc.identifier.volume14-
dc.identifier.issue9-
dc.identifier.spage11215-
dc.identifier.epage11224-
dc.identifier.isiWOS:000576958900013-
dc.publisher.placeUnited States-
dc.identifier.issnl1936-0851-

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