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Article: Photoelectric-Responsive Extracellular Matrix for Bone Engineering

TitlePhotoelectric-Responsive Extracellular Matrix for Bone Engineering
Authors
Keywordsphotoelectrons
Wnt/Ca2+ signaling pathway
bone regeneration
implants
bismuth sulfide/hydroxyapatite
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html
Citation
ACS Nano, 2019, v. 13 n. 11, p. 13581-13594 How to Cite?
AbstractUsing noninvasive stimulation of cells to control cell fate and improve bone regeneration by optical stimulation can achieve the aim of precisely orchestrating biological activities. In this study, we create a fast and repeatable photoelectric-responsive microenvironment around an implant using a bismuth sulfide/hydroxyapatite (BS/HAp) film. The unexpected increase of photocurrent on the BS/HAp film under near-infrared (NIR) light is mainly due to the depletion of holes through PO43– from HAp and interfacial charge transfer by HAp compared with BS. The electrons activate the Na+ channel of mesenchymal stem cells (MSCs) and change the cell adhesion in the intermediate environment. The behavior of MSCs is tuned by changing the photoelectronic microenvironment. RNA sequencing reveals that when photoelectrons transfer to the cell membrane, sodium ions flux and the membrane potential depolarizes to change the cell shape. Meanwhile, calcium ions fluxed and FDE1 was upregulated. Furthermore, the TCF/LEF in the cell nucleus began transcription to regulate the downstream genes involved in osteogenic differentiation, which is performed through the Wnt/Ca2+ signaling pathway. This research has created a biological therapeutic strategy, which can achieve in vitro remotely, precisely, and noninvasively controlling cell differentiation behaviors by tuning the in vivo photoelectric microenvironment using NIR light.
Persistent Identifierhttp://hdl.handle.net/10722/289807
ISSN
2020 Impact Factor: 15.881
2015 SCImago Journal Rankings: 7.120
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFU, J-
dc.contributor.authorLIU, X-
dc.contributor.authorTAN, L-
dc.contributor.authorCUI, Z-
dc.contributor.authorZHENG, Y-
dc.contributor.authorLIANG, Y-
dc.contributor.authorLI, Z-
dc.contributor.authorZHU, S-
dc.contributor.authorYeung, KWK-
dc.contributor.authorFENG, X-
dc.contributor.authorWANG, X-
dc.contributor.authorWU, S-
dc.date.accessioned2020-10-22T08:17:45Z-
dc.date.available2020-10-22T08:17:45Z-
dc.date.issued2019-
dc.identifier.citationACS Nano, 2019, v. 13 n. 11, p. 13581-13594-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/289807-
dc.description.abstractUsing noninvasive stimulation of cells to control cell fate and improve bone regeneration by optical stimulation can achieve the aim of precisely orchestrating biological activities. In this study, we create a fast and repeatable photoelectric-responsive microenvironment around an implant using a bismuth sulfide/hydroxyapatite (BS/HAp) film. The unexpected increase of photocurrent on the BS/HAp film under near-infrared (NIR) light is mainly due to the depletion of holes through PO43– from HAp and interfacial charge transfer by HAp compared with BS. The electrons activate the Na+ channel of mesenchymal stem cells (MSCs) and change the cell adhesion in the intermediate environment. The behavior of MSCs is tuned by changing the photoelectronic microenvironment. RNA sequencing reveals that when photoelectrons transfer to the cell membrane, sodium ions flux and the membrane potential depolarizes to change the cell shape. Meanwhile, calcium ions fluxed and FDE1 was upregulated. Furthermore, the TCF/LEF in the cell nucleus began transcription to regulate the downstream genes involved in osteogenic differentiation, which is performed through the Wnt/Ca2+ signaling pathway. This research has created a biological therapeutic strategy, which can achieve in vitro remotely, precisely, and noninvasively controlling cell differentiation behaviors by tuning the in vivo photoelectric microenvironment using NIR light.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/ancac3/index.html-
dc.relation.ispartofACS Nano-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectphotoelectrons-
dc.subjectWnt/Ca2+ signaling pathway-
dc.subjectbone regeneration-
dc.subjectimplants-
dc.subjectbismuth sulfide/hydroxyapatite-
dc.titlePhotoelectric-Responsive Extracellular Matrix for Bone Engineering-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.9b08115-
dc.identifier.pmid31697055-
dc.identifier.scopuseid_2-s2.0-85075005294-
dc.identifier.hkuros317560-
dc.identifier.volume13-
dc.identifier.issue11-
dc.identifier.spage13581-
dc.identifier.epage13594-
dc.identifier.isiWOS:000500650000131-
dc.publisher.placeUnited States-
dc.identifier.issnl1936-0851-

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