File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/s41598-020-72068-6
- Scopus: eid_2-s2.0-85091658667
- PMID: 32978449
- WOS: WOS:000577248100014
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study
Title | Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study |
---|---|
Authors | |
Keywords | Ozone Bronchoalveolar Lavage Fluid Methacholine |
Issue Date | 2020 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2020, v. 10, p. article no. 15739 How to Cite? |
Abstract | We used a randomized crossover experiment to estimate the effects of ozone (vs. clean air) exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours. Twenty-four hours after exposure, participants underwent bronchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K platform. We performed global and regional tests examining the ozone versus clean air effect on the DNA methylome and calculated Fisher-exact p-values for a series of univariate tests. We found little evidence of an overall effect of ozone on the DNA methylome but some suggestive changes in PLSCR1, HCAR1, and LINC00336 DNA methylation after ozone exposure relative to clean air. We observed some participant-to-participant heterogeneity in ozone responses. |
Persistent Identifier | http://hdl.handle.net/10722/289841 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bind, MAC | - |
dc.contributor.author | Rubin, DR | - |
dc.contributor.author | Cardenas, A | - |
dc.contributor.author | Dhingra, R | - |
dc.contributor.author | Ward-Caviness, C | - |
dc.contributor.author | Liu, Z | - |
dc.contributor.author | Mirowsky, J | - |
dc.contributor.author | Schwartz, JD | - |
dc.contributor.author | Diaz-Sanchez, D | - |
dc.contributor.author | Devlin, RB | - |
dc.date.accessioned | 2020-10-22T08:18:14Z | - |
dc.date.available | 2020-10-22T08:18:14Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Scientific Reports, 2020, v. 10, p. article no. 15739 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289841 | - |
dc.description.abstract | We used a randomized crossover experiment to estimate the effects of ozone (vs. clean air) exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours. Twenty-four hours after exposure, participants underwent bronchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K platform. We performed global and regional tests examining the ozone versus clean air effect on the DNA methylome and calculated Fisher-exact p-values for a series of univariate tests. We found little evidence of an overall effect of ozone on the DNA methylome but some suggestive changes in PLSCR1, HCAR1, and LINC00336 DNA methylation after ozone exposure relative to clean air. We observed some participant-to-participant heterogeneity in ozone responses. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Ozone | - |
dc.subject | Bronchoalveolar Lavage Fluid | - |
dc.subject | Methacholine | - |
dc.title | Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study | - |
dc.type | Article | - |
dc.identifier.email | Liu, Z: zhhliu@hku.hk | - |
dc.identifier.authority | Liu, Z=rp02429 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-020-72068-6 | - |
dc.identifier.pmid | 32978449 | - |
dc.identifier.pmcid | PMC7519112 | - |
dc.identifier.scopus | eid_2-s2.0-85091658667 | - |
dc.identifier.hkuros | 316245 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | article no. 15739 | - |
dc.identifier.epage | article no. 15739 | - |
dc.identifier.isi | WOS:000577248100014 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2045-2322 | - |