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Article: Vaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection

TitleVaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection
Authors
Kavian, NHachim, APoon, LMLValkenburg, SA
KeywordsInfluenza
ADCC
Antibodies
Peptide-mapping
Issue Date2020
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2020, v. 38 n. 37, p. 5885-5890 How to Cite?
DOI: http://dx.doi.org/10.1016/j.vaccine.2020.07.008
AbstractInfluenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in both the HA1 and HA2 regions. Vaccination of mice with single ADCC-peptides induced ADCC activity leading to partial protection from lethal influenza challenge, with increased survival, reduced viral loads, and reduced activation of NK cells in the lungs. Targeted vaccination strategies to elicit ADCC responses may provide an approach for universal vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/290006
ISSN
0264-410X
2021 Impact Factor: 4.169
2020 SCImago Journal Rankings: 1.585
PubMed Central ID
PMC7524583
ISI Accession Number ID
WOS:000557068900003

 

DC FieldValueLanguage
dc.contributor.authorKavian, N-
dc.contributor.authorHachim, A-
dc.contributor.authorPoon, LML-
dc.contributor.authorValkenburg, SA-
dc.date.accessioned2020-10-22T08:20:35Z-
dc.date.available2020-10-22T08:20:35Z-
dc.date.issued2020-
dc.identifier.citationVaccine, 2020, v. 38 n. 37, p. 5885-5890-
dc.identifier.issn0264-410X-
dc.identifier.urihttp://hdl.handle.net/10722/290006-
dc.description.abstractInfluenza-specific antibody dependent cellular cytotoxicity (ADCC) antibodies have a broad cross reactivity and potential as an immune correlate for universal vaccines. Peptide-mapping for ADCC reactivity of H1-HA and H7-HA proteins from human serum samples identified high ADCC-inducing peptides in both the HA1 and HA2 regions. Vaccination of mice with single ADCC-peptides induced ADCC activity leading to partial protection from lethal influenza challenge, with increased survival, reduced viral loads, and reduced activation of NK cells in the lungs. Targeted vaccination strategies to elicit ADCC responses may provide an approach for universal vaccines.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine-
dc.relation.ispartofVaccine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectInfluenza-
dc.subjectADCC-
dc.subjectAntibodies-
dc.subjectPeptide-mapping-
dc.titleVaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection-
dc.typeArticle-
dc.identifier.emailKavian, N: niloufar@hku.hk-
dc.identifier.emailHachim, A: ahachim@hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.emailValkenburg, SA: sophiev@hku.hk-
dc.identifier.authorityPoon, LML=rp00484-
dc.identifier.authorityValkenburg, SA=rp02141-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.vaccine.2020.07.008-
dc.identifier.pmid32718818-
dc.identifier.pmcidPMC7524583-
dc.identifier.scopuseid_2-s2.0-85088782356-
dc.identifier.hkuros316307-
dc.identifier.volume38-
dc.identifier.issue37-
dc.identifier.spage5885-
dc.identifier.epage5890-
dc.identifier.isiWOS:000557068900003-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0264-410X-

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