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Article: Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017–2018

TitleGlobal update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017–2018
Authors
KeywordsInfluenza
Neuraminidase inhibitor
Baloxavir
Susceptibility
Surveillance
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral
Citation
Antiviral Research, 2020, v. 175, p. article no. 104718 How to Cite?
AbstractThe global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012–13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the United States. For this annual report, the susceptibilities of influenza viruses to NAIs and baloxavir were analyzed. A total of 15409 viruses, collected by World Health Organization (WHO) recognized National Influenza Centers and other laboratories between May 2017 and May 2018, were assessed for phenotypic NAI susceptibility by five WHO Collaborating Centers (CCs). The 50% inhibitory concentration (IC50) was determined for oseltamivir, zanamivir, peramivir and laninamivir. Reduced inhibition (RI) or highly reduced inhibition (HRI) by one or more NAIs was exhibited by 0.8% of viruses tested (n = 122). The frequency of viruses with RI or HRI has remained low since this global analysis began (2012–13: 0.6%; 2013–14: 1.9%; 2014–15: 0.5%; 2015–16: 0.8%; 2016–17: 0.2%). PA gene sequence data, available from public databases (n = 13523), were screened for amino acid substitutions associated with reduced susceptibility to baloxavir (PA E23G/K/R, PA A36V, PA A37T, PA I38F/M/T/L, PA E119D, PA E199G): 11 (0.08%) viruses possessed such substitutions. Five of them were included in phenotypic baloxavir susceptibility analysis by two WHO CCs and IC50 values were determined. The PA variant viruses showed 6–17-fold reduced susceptibility to baloxavir. Overall, in the 2017–18 period the frequency of circulating influenza viruses with reduced susceptibility to NAIs or baloxavir was low, but continued monitoring is important.
Persistent Identifierhttp://hdl.handle.net/10722/290010
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.500
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTakashita, E-
dc.contributor.authorDaniels, RS-
dc.contributor.authorFujisaki, S-
dc.contributor.authorGregory, V-
dc.contributor.authorGubareva, LV-
dc.contributor.authorHuang, W-
dc.contributor.authorHurt, AC-
dc.contributor.authorLackenby, A-
dc.contributor.authorNguyen, HT-
dc.contributor.authorPereyaslov, D-
dc.contributor.authorRoe, M-
dc.contributor.authorSamaan, M-
dc.contributor.authorSubbarao, K-
dc.contributor.authorTse, H-
dc.contributor.authorWang, D-
dc.contributor.authorYen, HL-
dc.contributor.authorZhang, W-
dc.contributor.authorMeijer, A-
dc.date.accessioned2020-10-22T08:20:39Z-
dc.date.available2020-10-22T08:20:39Z-
dc.date.issued2020-
dc.identifier.citationAntiviral Research, 2020, v. 175, p. article no. 104718-
dc.identifier.issn0166-3542-
dc.identifier.urihttp://hdl.handle.net/10722/290010-
dc.description.abstractThe global analysis of neuraminidase inhibitor (NAI) susceptibility of influenza viruses has been conducted since the 2012–13 period. In 2018 a novel cap-dependent endonuclease inhibitor, baloxavir, that targets polymerase acidic subunit (PA) was approved for the treatment of influenza virus infection in Japan and the United States. For this annual report, the susceptibilities of influenza viruses to NAIs and baloxavir were analyzed. A total of 15409 viruses, collected by World Health Organization (WHO) recognized National Influenza Centers and other laboratories between May 2017 and May 2018, were assessed for phenotypic NAI susceptibility by five WHO Collaborating Centers (CCs). The 50% inhibitory concentration (IC50) was determined for oseltamivir, zanamivir, peramivir and laninamivir. Reduced inhibition (RI) or highly reduced inhibition (HRI) by one or more NAIs was exhibited by 0.8% of viruses tested (n = 122). The frequency of viruses with RI or HRI has remained low since this global analysis began (2012–13: 0.6%; 2013–14: 1.9%; 2014–15: 0.5%; 2015–16: 0.8%; 2016–17: 0.2%). PA gene sequence data, available from public databases (n = 13523), were screened for amino acid substitutions associated with reduced susceptibility to baloxavir (PA E23G/K/R, PA A36V, PA A37T, PA I38F/M/T/L, PA E119D, PA E199G): 11 (0.08%) viruses possessed such substitutions. Five of them were included in phenotypic baloxavir susceptibility analysis by two WHO CCs and IC50 values were determined. The PA variant viruses showed 6–17-fold reduced susceptibility to baloxavir. Overall, in the 2017–18 period the frequency of circulating influenza viruses with reduced susceptibility to NAIs or baloxavir was low, but continued monitoring is important.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral-
dc.relation.ispartofAntiviral Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectInfluenza-
dc.subjectNeuraminidase inhibitor-
dc.subjectBaloxavir-
dc.subjectSusceptibility-
dc.subjectSurveillance-
dc.titleGlobal update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017–2018-
dc.typeArticle-
dc.identifier.emailYen, HL: hyen@hku.hk-
dc.identifier.authorityYen, HL=rp00304-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.antiviral.2020.104718-
dc.identifier.pmid32004620-
dc.identifier.scopuseid_2-s2.0-85078856362-
dc.identifier.hkuros316548-
dc.identifier.volume175-
dc.identifier.spagearticle no. 104718-
dc.identifier.epagearticle no. 104718-
dc.identifier.isiWOS:000523597100006-
dc.publisher.placeNetherlands-
dc.identifier.issnl0166-3542-

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