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Article: From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome

TitleFrom birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome
Authors
KeywordsCesarean Birth
Labor
Gut Microbiota
Metabolites
Issue Date2020
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 2020, v. 160 n. 1, p. 128-144.e10 How to Cite?
AbstractBackground & Aims: Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. Methods: Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolonged labor and breastfeeding; infant gut microbiota, metabolites, and IgA; and childhood body mass index and atopy in 1667 infants. Results: After both cesarean birth and prolonged labor with a first pregnancy, a higher Enterobacteriaceae/Bacteroidaceae ratio at 3 months was the dominant path to overweight; higher Enterobacteriaceae/Bacteroidaceae ratios and Clostridioides difficile colonization at 12 months were the main pathway to atopic sensitization. Depletion of Bifidobacterium after prolonged labor was a secondary pathway to overweight. Influenced by C difficile colonization at 3 months, metabolites propionate and formate were secondary pathways to child outcomes, with a key finding that formate was at the intersection of several paths. Conclusions: Pathways from cesarean section and first pregnancy to child overweight and atopy share many common mediators of the infant gut microbiome, notably C difficile colonization.
Persistent Identifierhttp://hdl.handle.net/10722/290017
ISSN
2020 Impact Factor: 22.682
2020 SCImago Journal Rankings: 7.828
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVu, K-
dc.contributor.authorLou, W-
dc.contributor.authorTun, HM-
dc.contributor.authorKonya, TB-
dc.contributor.authorMorales-Lizcano, NP-
dc.contributor.authorChari, RS-
dc.contributor.authorField, CJ-
dc.contributor.authorGuttman, DS-
dc.contributor.authorMandal, R-
dc.contributor.authorWishart, DS-
dc.contributor.authorAzad, MB-
dc.contributor.authorBecker, AB-
dc.contributor.authorMandhane, PJ-
dc.contributor.authorMoraes, TJ-
dc.contributor.authorLefebvre, DL-
dc.contributor.authorSears, MR-
dc.contributor.authorTurvey, SE-
dc.contributor.authorSubbarao, P-
dc.contributor.authorScott, JA-
dc.contributor.authorKozyrskyj, AL-
dc.date.accessioned2020-10-22T08:20:46Z-
dc.date.available2020-10-22T08:20:46Z-
dc.date.issued2020-
dc.identifier.citationGastroenterology, 2020, v. 160 n. 1, p. 128-144.e10-
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/290017-
dc.description.abstractBackground & Aims: Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. Methods: Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolonged labor and breastfeeding; infant gut microbiota, metabolites, and IgA; and childhood body mass index and atopy in 1667 infants. Results: After both cesarean birth and prolonged labor with a first pregnancy, a higher Enterobacteriaceae/Bacteroidaceae ratio at 3 months was the dominant path to overweight; higher Enterobacteriaceae/Bacteroidaceae ratios and Clostridioides difficile colonization at 12 months were the main pathway to atopic sensitization. Depletion of Bifidobacterium after prolonged labor was a secondary pathway to overweight. Influenced by C difficile colonization at 3 months, metabolites propionate and formate were secondary pathways to child outcomes, with a key finding that formate was at the intersection of several paths. Conclusions: Pathways from cesarean section and first pregnancy to child overweight and atopy share many common mediators of the infant gut microbiome, notably C difficile colonization.-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro-
dc.relation.ispartofGastroenterology-
dc.subjectCesarean Birth-
dc.subjectLabor-
dc.subjectGut Microbiota-
dc.subjectMetabolites-
dc.titleFrom birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome-
dc.typeArticle-
dc.identifier.emailTun, HM: heinmtun@hku.hk-
dc.identifier.authorityTun, HM=rp02389-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/j.gastro.2020.08.053-
dc.identifier.pmid32946900-
dc.identifier.scopuseid_2-s2.0-85097467863-
dc.identifier.hkuros316834-
dc.identifier.volume160-
dc.identifier.issue1-
dc.identifier.spage128-
dc.identifier.epage144.e10-
dc.identifier.isiWOS:000600644700028-
dc.publisher.placeUnited States-
dc.identifier.issnl0016-5085-

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