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Article: 5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function

Title5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function
Authors
Keywords5‐HT1A receptor
GABA
glutamate
sensorimotor function
vestibular nucleus
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
The Journal of Physiology, 2021, v. 599 n. 1, p. 253-267 How to Cite?
AbstractWhile the anxiolytic effects of serotonergic neuromodulation are well studied, its role in sensorimotor coordination and postural control is unclear. In this study, we show that an increase of serotonin (5‐hydroxytryptamine, 5‐HT) at the medial vestibular nucleus (MVN), a brainstem centre for vestibulospinal coordination, by either direct cannula administration or chemogenetic stimulation of MVN‐projecting serotonergic neurons, adversely affected performance of rats in vestibular‐mediated tasks, including negative geotaxis, balance beam and rota‐rod tests. Application of the 5‐HT1 and 5‐HT7 receptor co‐agonist 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin recapitulated the effect of 5‐HT, while co‐administration of the specific 5‐HT1A receptor antagonist WAY 100135 effectively abolished all 5‐HT‐induced behavioural deficits. This indicated that 5‐HT1A receptors mediated the effects of 5‐HT in the rat MVN. Using whole‐cell patch‐clamp recording, we demonstrated that 5‐HT1A receptor activation attenuated both evoked excitatory and evoked inhibitory postsynaptic currents through a presynaptic mechanism in the rat MVN. The results thus highlight the 5‐HT1A receptor as the gain controller of vestibular‐related brainstem circuits for posture and balance.
Persistent Identifierhttp://hdl.handle.net/10722/290051
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 1.708
ISI Accession Number ID
Grants

 

DC FieldValueLanguage
dc.contributor.authorHan, L-
dc.contributor.authorWu, KLK-
dc.contributor.authorKwan, PY-
dc.contributor.authorChua, OWH-
dc.contributor.authorShum, DKY-
dc.contributor.authorChan, YS-
dc.date.accessioned2020-10-22T08:21:23Z-
dc.date.available2020-10-22T08:21:23Z-
dc.date.issued2021-
dc.identifier.citationThe Journal of Physiology, 2021, v. 599 n. 1, p. 253-267-
dc.identifier.issn0022-3751-
dc.identifier.urihttp://hdl.handle.net/10722/290051-
dc.description.abstractWhile the anxiolytic effects of serotonergic neuromodulation are well studied, its role in sensorimotor coordination and postural control is unclear. In this study, we show that an increase of serotonin (5‐hydroxytryptamine, 5‐HT) at the medial vestibular nucleus (MVN), a brainstem centre for vestibulospinal coordination, by either direct cannula administration or chemogenetic stimulation of MVN‐projecting serotonergic neurons, adversely affected performance of rats in vestibular‐mediated tasks, including negative geotaxis, balance beam and rota‐rod tests. Application of the 5‐HT1 and 5‐HT7 receptor co‐agonist 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin recapitulated the effect of 5‐HT, while co‐administration of the specific 5‐HT1A receptor antagonist WAY 100135 effectively abolished all 5‐HT‐induced behavioural deficits. This indicated that 5‐HT1A receptors mediated the effects of 5‐HT in the rat MVN. Using whole‐cell patch‐clamp recording, we demonstrated that 5‐HT1A receptor activation attenuated both evoked excitatory and evoked inhibitory postsynaptic currents through a presynaptic mechanism in the rat MVN. The results thus highlight the 5‐HT1A receptor as the gain controller of vestibular‐related brainstem circuits for posture and balance.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751-
dc.relation.ispartofThe Journal of Physiology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subject5‐HT1A receptor-
dc.subjectGABA-
dc.subjectglutamate-
dc.subjectsensorimotor function-
dc.subjectvestibular nucleus-
dc.title5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function-
dc.typeArticle-
dc.identifier.emailWu, KLK: lwu03@hku.hk-
dc.identifier.emailKwan, PY: pykwanaa@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.authorityChan, YS=rp00318-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1113/JP280610-
dc.identifier.pmid33006159-
dc.identifier.scopuseid_2-s2.0-85093536952-
dc.identifier.hkuros316906-
dc.identifier.volume599-
dc.identifier.issue1-
dc.identifier.spage253-
dc.identifier.epage267-
dc.identifier.isiWOS:000581126300001-
dc.publisher.placeUnited Kingdom-
dc.relation.projectSelective recruitment of inhibitory interneurons to vestibular microcircuits for distinct behaviour-
dc.identifier.issnl0022-3751-

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