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Article: Centrosomal protein TAX1BP2 inhibits centrosome-microtubules aberrations induced by hepatitis B virus X oncoprotein

TitleCentrosomal protein TAX1BP2 inhibits centrosome-microtubules aberrations induced by hepatitis B virus X oncoprotein
Authors
KeywordsHBx
TAX1BP2
Hepatocellular carcinoma
Centrosome
Microtubules
Issue Date2020
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2020, v. 492, p. 147-161 How to Cite?
AbstractLiver cancer (hepatocellular carcinoma, HCC) is one of the most prevalent cancers worldwide. Several etiological factors of HCC, including hepatitis B or hepatitis C virus infection, liver cirrhosis and aflatoxin B1 intake has been identified. HBx, which is an oncogenic protein encoded by the hepatitis B virus, is strongly associated with hepatocarcinogenesis. Using stable HBx-expressing cell, we showed that HBx induced chromosome gain, with amplification of centrosomes numbers and deregulation of centrosome ultrastructure. To dissect the mechanism for chromosome instability, our result revealed that HBx contributed to a hyperactive centrosome-microtubule dynamics by accelerating microtubule nucleation and polymerization. Further investigations suggested that HBx interacted with a centrosome linker protein TAX1BP2, which has previously been shown to function as an intrinsic block of centrosome amplification and a tumour suppressor in HCC. Restoring TAX1BP2 was able to block HBx-mediated centrosome amplification and abolish the HBx-mediated centrosome aberration, thereby suppressing chromosome instability. Thus, we demonstrate here a mechanism by which HBx deregulates centrosome-microtubule dynamics through interacting with TAX1BP2, which underlines the possibility of restoration of TAX1BP2 to rescue cells from chromosome instability.
Persistent Identifierhttp://hdl.handle.net/10722/290052
ISSN
2020 Impact Factor: 8.679
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, SK-
dc.contributor.authorTang, HC-
dc.contributor.authorLEUNG, MMH-
dc.contributor.authorZou, W-
dc.contributor.authorChan, WL-
dc.contributor.authorZhou, Y-
dc.contributor.authorNg, IOL-
dc.contributor.authorChing, YP-
dc.date.accessioned2020-10-22T08:21:24Z-
dc.date.available2020-10-22T08:21:24Z-
dc.date.issued2020-
dc.identifier.citationCancer Letters, 2020, v. 492, p. 147-161-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/290052-
dc.description.abstractLiver cancer (hepatocellular carcinoma, HCC) is one of the most prevalent cancers worldwide. Several etiological factors of HCC, including hepatitis B or hepatitis C virus infection, liver cirrhosis and aflatoxin B1 intake has been identified. HBx, which is an oncogenic protein encoded by the hepatitis B virus, is strongly associated with hepatocarcinogenesis. Using stable HBx-expressing cell, we showed that HBx induced chromosome gain, with amplification of centrosomes numbers and deregulation of centrosome ultrastructure. To dissect the mechanism for chromosome instability, our result revealed that HBx contributed to a hyperactive centrosome-microtubule dynamics by accelerating microtubule nucleation and polymerization. Further investigations suggested that HBx interacted with a centrosome linker protein TAX1BP2, which has previously been shown to function as an intrinsic block of centrosome amplification and a tumour suppressor in HCC. Restoring TAX1BP2 was able to block HBx-mediated centrosome amplification and abolish the HBx-mediated centrosome aberration, thereby suppressing chromosome instability. Thus, we demonstrate here a mechanism by which HBx deregulates centrosome-microtubule dynamics through interacting with TAX1BP2, which underlines the possibility of restoration of TAX1BP2 to rescue cells from chromosome instability.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet-
dc.relation.ispartofCancer Letters-
dc.subjectHBx-
dc.subjectTAX1BP2-
dc.subjectHepatocellular carcinoma-
dc.subjectCentrosome-
dc.subjectMicrotubules-
dc.titleCentrosomal protein TAX1BP2 inhibits centrosome-microtubules aberrations induced by hepatitis B virus X oncoprotein-
dc.typeArticle-
dc.identifier.emailZou, W: ailis@hku.hk-
dc.identifier.emailChan, WL: wlc30@hku.hk-
dc.identifier.emailZhou, Y: yzhou@hku.hk-
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.emailChing, YP: ypching@hku.hk-
dc.identifier.authorityNg, IOL=rp00335-
dc.identifier.authorityChing, YP=rp00469-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2020.08.005-
dc.identifier.pmid32827601-
dc.identifier.scopuseid_2-s2.0-85090293607-
dc.identifier.hkuros316192-
dc.identifier.volume492-
dc.identifier.spage147-
dc.identifier.epage161-
dc.identifier.isiWOS:000581518000014-
dc.publisher.placeIreland-
dc.identifier.issnl0304-3835-

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