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Article: Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation

TitleMultifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation
Authors
Keywordsbiomimetic mineralization
bone‐tissue engineering
black phosphorus nanosheets
ECM microenvironment
high‐strength nanoengineered hydrogels
Issue Date2019
PublisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html
Citation
Small, 2019, v. 15 n. 41, p. article no. 1901560 How to Cite?
AbstractTissue‐engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone‐tissue regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/290614
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWANG, Z-
dc.contributor.authorZHAO, J-
dc.contributor.authorTANG, W-
dc.contributor.authorHU, L-
dc.contributor.authorCHEN, X-
dc.contributor.authorSU, Y-
dc.contributor.authorZOU, C-
dc.contributor.authorWANG, J-
dc.contributor.authorLu, WW-
dc.contributor.authorZHEN, W-
dc.contributor.authorZHANG, R-
dc.contributor.authorYANG, D-
dc.contributor.authorPENG, S-
dc.date.accessioned2020-11-02T05:44:42Z-
dc.date.available2020-11-02T05:44:42Z-
dc.date.issued2019-
dc.identifier.citationSmall, 2019, v. 15 n. 41, p. article no. 1901560-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/290614-
dc.description.abstractTissue‐engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) hydrogels with tunable mechanical properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) hydrogels are constructed by addition of ultrathin 2D black phosphorus (BP) nanosheets to the DN hydrogels with multiple functions for mimicking the ECM microenvironment to induce tissue regeneration. Notably, it is found that the BP nanosheets exhibit intrinsic properties for induced CaP crystal particle formation and therefore improve the mineralization ability of NE hydrogels. Finally, in vitro and in vivo data demonstrate that the BP nanosheets, mineralized CaP crystal nanoparticles, and excellent mechanical properties provide a favorable ECM microenvironment to mediate greater osteogenic cell differentiation and bone regeneration. Consequently, the combination of bioactive chemical materials and excellent mechanical stimuli of NE hydrogels inspire novel engineering strategies for bone‐tissue regeneration.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html-
dc.relation.ispartofSmall-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbiomimetic mineralization-
dc.subjectbone‐tissue engineering-
dc.subjectblack phosphorus nanosheets-
dc.subjectECM microenvironment-
dc.subjecthigh‐strength nanoengineered hydrogels-
dc.titleMultifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation-
dc.typeArticle-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.authorityLu, WW=rp00411-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.201901560-
dc.identifier.pmid31423735-
dc.identifier.scopuseid_2-s2.0-85070822771-
dc.identifier.hkuros317773-
dc.identifier.volume15-
dc.identifier.issue41-
dc.identifier.spagearticle no. 1901560-
dc.identifier.epagearticle no. 1901560-
dc.identifier.isiWOS:000481805900001-
dc.publisher.placeGermany-
dc.identifier.issnl1613-6810-

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