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- Publisher Website: 10.1136/bmjsrh-2020-200639
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- PMID: 32718983
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Article: Women’s age and total motile normal morphology sperm count predict fecundability: a prospective cohort study
Title | Women’s age and total motile normal morphology sperm count predict fecundability: a prospective cohort study |
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Authors | |
Keywords | counselling family planning service provision infertility natural family planning |
Issue Date | 2020 |
Publisher | BMJ Group. The Journal's web site is located at https://srh.bmj.com/ |
Citation | BMJ Sexual & Reproductive Health, 2020, v. 46 n. 4, p. 279-286 How to Cite? |
Abstract | Objective: This study investigated the role of women’s age, serum anti-Müllerian hormone (AMH) level and semen parameters in predicting fecundability.
Methods: This was a prospective cohort study on couples attending for preconceptional health check. Occurrence of conception at 1 year after ceasing contraception and time to pregnancy were noted by telephone follow-up. The women’s age, serum AMH level and total motile normal morphology sperm count (TMNC) were compared between those who conceived and those who did not after 1 year; their independent predictive value on conception at 1 year was analysed by logistic regression. Among those conceiving within 1 year, Spearman’s correlations between time to pregnancy and the clinical parameters were studied.
Results: Of the 100 couples analysed, we found younger age of the women (p=0.008), higher serum AMH level (p=0.038) and higher TMNC (p=0.015) in those that conceived within 1 year. Multivariate logistic regression found that women’s age (OR 0.867, 95% CI 0.761 to 0.988, p=0.032) and TMNC (OR 1.089, 95% 1.001–1.185, p=0.047), but not serum AMH level, significantly predicted conception within 1 year. Among those that conceived within 1 year, none of the parameters analysed were correlated with time to pregnancy within 1 year.
Conclusions: Women’s age and TNMC are significant independent predictors of conception within 1 year. No parameter was shown to predict the time to pregnancy within 1 year. This finding can aid preconceptional counselling of couples who are planning for pregnancy. |
Persistent Identifier | http://hdl.handle.net/10722/290703 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 0.849 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, MT | - |
dc.contributor.author | Li, HWR | - |
dc.contributor.author | Wong, CYG | - |
dc.contributor.author | Yeung, WSB | - |
dc.contributor.author | Ho, PC | - |
dc.contributor.author | Ng, EHY | - |
dc.date.accessioned | 2020-11-02T05:45:56Z | - |
dc.date.available | 2020-11-02T05:45:56Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | BMJ Sexual & Reproductive Health, 2020, v. 46 n. 4, p. 279-286 | - |
dc.identifier.issn | 2515-1991 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290703 | - |
dc.description.abstract | Objective: This study investigated the role of women’s age, serum anti-Müllerian hormone (AMH) level and semen parameters in predicting fecundability. Methods: This was a prospective cohort study on couples attending for preconceptional health check. Occurrence of conception at 1 year after ceasing contraception and time to pregnancy were noted by telephone follow-up. The women’s age, serum AMH level and total motile normal morphology sperm count (TMNC) were compared between those who conceived and those who did not after 1 year; their independent predictive value on conception at 1 year was analysed by logistic regression. Among those conceiving within 1 year, Spearman’s correlations between time to pregnancy and the clinical parameters were studied. Results: Of the 100 couples analysed, we found younger age of the women (p=0.008), higher serum AMH level (p=0.038) and higher TMNC (p=0.015) in those that conceived within 1 year. Multivariate logistic regression found that women’s age (OR 0.867, 95% CI 0.761 to 0.988, p=0.032) and TMNC (OR 1.089, 95% 1.001–1.185, p=0.047), but not serum AMH level, significantly predicted conception within 1 year. Among those that conceived within 1 year, none of the parameters analysed were correlated with time to pregnancy within 1 year. Conclusions: Women’s age and TNMC are significant independent predictors of conception within 1 year. No parameter was shown to predict the time to pregnancy within 1 year. This finding can aid preconceptional counselling of couples who are planning for pregnancy. | - |
dc.language | eng | - |
dc.publisher | BMJ Group. The Journal's web site is located at https://srh.bmj.com/ | - |
dc.relation.ispartof | BMJ Sexual & Reproductive Health | - |
dc.rights | BMJ Sexual & Reproductive Health. Copyright © BMJ Group. | - |
dc.rights | This article has been accepted for publication in BMJ Sexual & Reproductive Health, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmjsrh-2020-200639. © Author(s) (or their employer(s)) 2020. No commercial re-use. Published by BMJ. | - |
dc.subject | counselling | - |
dc.subject | family planning service provision | - |
dc.subject | infertility | - |
dc.subject | natural family planning | - |
dc.title | Women’s age and total motile normal morphology sperm count predict fecundability: a prospective cohort study | - |
dc.type | Article | - |
dc.identifier.email | Lam, MT: mtlam@hku.hk | - |
dc.identifier.email | Li, HWR: raymondli@hku.hk | - |
dc.identifier.email | Yeung, WSB: wsbyeung@hku.hk | - |
dc.identifier.email | Ho, PC: pcho@hku.hk | - |
dc.identifier.email | Ng, EHY: nghye@hku.hk | - |
dc.identifier.authority | Li, HWR=rp01649 | - |
dc.identifier.authority | Yeung, WSB=rp00331 | - |
dc.identifier.authority | Ho, PC=rp00325 | - |
dc.identifier.authority | Ng, EHY=rp00426 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1136/bmjsrh-2020-200639 | - |
dc.identifier.pmid | 32718983 | - |
dc.identifier.scopus | eid_2-s2.0-85089655107 | - |
dc.identifier.hkuros | 318096 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 279 | - |
dc.identifier.epage | 286 | - |
dc.identifier.isi | WOS:000580393000007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2515-1991 | - |