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Article: Multi-route respiratory infection: When a transmission route may dominate

TitleMulti-route respiratory infection: When a transmission route may dominate
Authors
KeywordsBioaerosol
Respiratory infection
Multi-route transmission
Short-range airborne route
Long-range airborne route
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenv
Citation
Science of the Total Environment, 2020, v. 752, p. article no. 141856 How to Cite?
AbstractThe exact transmission route of many respiratory infectious diseases remains a subject for debate to date. The relative contribution ratio of each transmission route is largely undetermined, which is affected by environmental conditions, human behaviour, the host and the microorganism. In this study, a detailed mathematical model is developed to investigate the relative contributions of different transmission routes to a multi-route transmitted respiratory infection. The following transmission routes are considered: long-range airborne transmission, short-range airborne transmission, direction inhalation of medium droplets or droplet nuclei, direct deposition of droplets of all sizes, direct and indirect contact route. It is illustrated that all transmission routes can dominate the total transmission risk under different scenarios. Influential parameters considered include the dose-response rate of different routes, droplet governing size that determines pathogen content in droplets, exposure distance, and pathogen dose transported to the hand of infector. Our multi-route transmission model provided a comprehensive but straightforward method to evaluate the probability of respiratory diseases transmission via different routes. It also established a basis for predicting the impact of individual-level intervention methods such as increasing close-contact distance and wearing protective masks.
Persistent Identifierhttp://hdl.handle.net/10722/290828
ISSN
2019 Impact Factor: 6.551
2015 SCImago Journal Rankings: 1.702
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, CX-
dc.contributor.authorLi, Y-
dc.contributor.authorWei, J-
dc.contributor.authorCotton, S-
dc.contributor.authorHamilton, M-
dc.contributor.authorWang, L-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2020-11-02T05:47:42Z-
dc.date.available2020-11-02T05:47:42Z-
dc.date.issued2020-
dc.identifier.citationScience of the Total Environment, 2020, v. 752, p. article no. 141856-
dc.identifier.issn0048-9697-
dc.identifier.urihttp://hdl.handle.net/10722/290828-
dc.description.abstractThe exact transmission route of many respiratory infectious diseases remains a subject for debate to date. The relative contribution ratio of each transmission route is largely undetermined, which is affected by environmental conditions, human behaviour, the host and the microorganism. In this study, a detailed mathematical model is developed to investigate the relative contributions of different transmission routes to a multi-route transmitted respiratory infection. The following transmission routes are considered: long-range airborne transmission, short-range airborne transmission, direction inhalation of medium droplets or droplet nuclei, direct deposition of droplets of all sizes, direct and indirect contact route. It is illustrated that all transmission routes can dominate the total transmission risk under different scenarios. Influential parameters considered include the dose-response rate of different routes, droplet governing size that determines pathogen content in droplets, exposure distance, and pathogen dose transported to the hand of infector. Our multi-route transmission model provided a comprehensive but straightforward method to evaluate the probability of respiratory diseases transmission via different routes. It also established a basis for predicting the impact of individual-level intervention methods such as increasing close-contact distance and wearing protective masks.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenv-
dc.relation.ispartofScience of the Total Environment-
dc.subjectBioaerosol-
dc.subjectRespiratory infection-
dc.subjectMulti-route transmission-
dc.subjectShort-range airborne route-
dc.subjectLong-range airborne route-
dc.titleMulti-route respiratory infection: When a transmission route may dominate-
dc.typeArticle-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.scitotenv.2020.141856-
dc.identifier.pmid32889280-
dc.identifier.pmcidPMC7439990-
dc.identifier.scopuseid_2-s2.0-85090006930-
dc.identifier.hkuros318582-
dc.identifier.volume752-
dc.identifier.spagearticle no. 141856-
dc.identifier.epagearticle no. 141856-
dc.identifier.isiWOS:000588243900061-
dc.publisher.placeNetherlands-
dc.identifier.issnl0048-9697-

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