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Article: Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces
Title | Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces |
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Authors | |
Keywords | biomimetics controlled study nanoemulsion nonhuman protein cross linking |
Issue Date | 2016 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2016, v. 7, p. article no. 12934 How to Cite? |
Abstract | All-aqueous emulsions exploit spontaneous liquid–liquid separation and due to their water-based nature are particular advantageous for the biocompatible storage and processing of biomacromolecules. However, the ultralow interfacial tensions characteristic of all-aqueous interfaces represent an inherent limitation to the use of thermally adsorbed particles to achieve emulsion stability. Here, we use protein nanofibrils to generate colloidosome-like two-dimensional crosslinked networks of nanostructures templated by all-aqueous emulsions, which we term fibrillosomes. We show that this approach not only allows us to operate below the thermal limit at ultra-low surface tensions but also yields structures that are stable even in the complete absence of an interface. Moreover, we show that the growth and multilayer deposition of fibrils allows us to control the thickness of the capsule shells. These results open up the possibility of stabilizing aqueous two-phase systems using natural proteins, and creating self-standing protein capsules without the requirement for three-phase emulsions or water/oil interfaces. |
Persistent Identifier | http://hdl.handle.net/10722/290918 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | SONG, Y | - |
dc.contributor.author | Shimanovich, U | - |
dc.contributor.author | Michaels, TCT | - |
dc.contributor.author | MA, Q | - |
dc.contributor.author | LI, J | - |
dc.contributor.author | Knowles, TPJ | - |
dc.contributor.author | Shum, HC | - |
dc.date.accessioned | 2020-11-02T05:48:56Z | - |
dc.date.available | 2020-11-02T05:48:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nature Communications, 2016, v. 7, p. article no. 12934 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290918 | - |
dc.description.abstract | All-aqueous emulsions exploit spontaneous liquid–liquid separation and due to their water-based nature are particular advantageous for the biocompatible storage and processing of biomacromolecules. However, the ultralow interfacial tensions characteristic of all-aqueous interfaces represent an inherent limitation to the use of thermally adsorbed particles to achieve emulsion stability. Here, we use protein nanofibrils to generate colloidosome-like two-dimensional crosslinked networks of nanostructures templated by all-aqueous emulsions, which we term fibrillosomes. We show that this approach not only allows us to operate below the thermal limit at ultra-low surface tensions but also yields structures that are stable even in the complete absence of an interface. Moreover, we show that the growth and multilayer deposition of fibrils allows us to control the thickness of the capsule shells. These results open up the possibility of stabilizing aqueous two-phase systems using natural proteins, and creating self-standing protein capsules without the requirement for three-phase emulsions or water/oil interfaces. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | biomimetics | - |
dc.subject | controlled study | - |
dc.subject | nanoemulsion | - |
dc.subject | nonhuman | - |
dc.subject | protein cross linking | - |
dc.title | Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces | - |
dc.type | Article | - |
dc.identifier.email | Shum, HC: ashum@hku.hk | - |
dc.identifier.authority | Shum, HC=rp01439 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/ncomms12934 | - |
dc.identifier.pmid | 27725629 | - |
dc.identifier.pmcid | PMC5062572 | - |
dc.identifier.scopus | eid_2-s2.0-84991293590 | - |
dc.identifier.hkuros | 317644 | - |
dc.identifier.volume | 7 | - |
dc.identifier.spage | article no. 12934 | - |
dc.identifier.epage | article no. 12934 | - |
dc.identifier.isi | WOS:000385550300001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |