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Article: Atopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization

TitleAtopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization
Authors
KeywordsAllergens
Allergy and immunology
Fel d1 protein
Irritable bowel syndrome
Issue Date2020
PublisherKorean Society of Neurogastroenterology and Motility. The Journal's web site is located at http://www.jnmjournal.org/
Citation
Journal of Neurogastroenterology and Motility, 2020, v. 26 n. 2, p. 267-273 How to Cite?
AbstractBackground/Aims The relationship between animal exposure and irritable bowel syndrome (IBS) is debated. Epidemiological studies have shown that atopy is more prevalent in IBS patients and vice versa. We set out to examine the association between animal danders sensitization and IBS-like symptoms in atopic patients. Methods We recruited 69 consecutive atopic patients from the allergy clinic of a tertiary hospital. Subjects completed validated bowel questionnaires, underwent skin prick test, blood was collected for serum total immunoglobulin E, and ImmunoCAP immune solid-phase allergen chip (ISAC) IgE multiplex assay. Results Twenty-eight (41.0%) atopic patients fulfilled the Rome III IBS criteria (atopy-IBS). There were no differences in gender, age, pet ownership, total serum IgE, or food allergen sensitization between atopy-IBS group and atopy-non-IBS group. We found that atopy-IBS group had significantly higher number of positive skin prick test for cat dander (64.3% vs 24.4%, P < 0.001), dog dander (64.3% vs 41.5%, P = 0.015) and weed pollens (32.1% vs 14.6%, P = 0.050) compared to atopy-non-IBS group. Out of 112 components from 51 allergen sources (both aeroallergen and food allergens), only Fel d1 (a major cat dander antigen) IgE is significantly higher in atopy-IBS group than atopy-non-IBS group (21.4% vs 2.4%, P = 0.029). Majority of atopy-IBS patients had mixed-type IBS. Conclusions We demonstrated an association between animal danders sensitization, in particular cat dander sensitization, and IBS-like symptoms in atopic patients. Future studies are needed to explore the relationship between aeroallergen and functional gastrointestinal disorders. Sensitization may be related to the pathophysiology of IBS or it could be that we are missing aeroallergen-induced gut allergy. © 2020 The Korean Society of Neurogastroenterology and Motility
Persistent Identifierhttp://hdl.handle.net/10722/290937
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.944
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSiah, KTH-
dc.contributor.authorSantosa, A-
dc.contributor.authorCheung, CKY-
dc.contributor.authorSoh, AYS-
dc.contributor.authorBigliardi, PL-
dc.date.accessioned2020-11-02T05:49:13Z-
dc.date.available2020-11-02T05:49:13Z-
dc.date.issued2020-
dc.identifier.citationJournal of Neurogastroenterology and Motility, 2020, v. 26 n. 2, p. 267-273-
dc.identifier.issn2093-0879-
dc.identifier.urihttp://hdl.handle.net/10722/290937-
dc.description.abstractBackground/Aims The relationship between animal exposure and irritable bowel syndrome (IBS) is debated. Epidemiological studies have shown that atopy is more prevalent in IBS patients and vice versa. We set out to examine the association between animal danders sensitization and IBS-like symptoms in atopic patients. Methods We recruited 69 consecutive atopic patients from the allergy clinic of a tertiary hospital. Subjects completed validated bowel questionnaires, underwent skin prick test, blood was collected for serum total immunoglobulin E, and ImmunoCAP immune solid-phase allergen chip (ISAC) IgE multiplex assay. Results Twenty-eight (41.0%) atopic patients fulfilled the Rome III IBS criteria (atopy-IBS). There were no differences in gender, age, pet ownership, total serum IgE, or food allergen sensitization between atopy-IBS group and atopy-non-IBS group. We found that atopy-IBS group had significantly higher number of positive skin prick test for cat dander (64.3% vs 24.4%, P < 0.001), dog dander (64.3% vs 41.5%, P = 0.015) and weed pollens (32.1% vs 14.6%, P = 0.050) compared to atopy-non-IBS group. Out of 112 components from 51 allergen sources (both aeroallergen and food allergens), only Fel d1 (a major cat dander antigen) IgE is significantly higher in atopy-IBS group than atopy-non-IBS group (21.4% vs 2.4%, P = 0.029). Majority of atopy-IBS patients had mixed-type IBS. Conclusions We demonstrated an association between animal danders sensitization, in particular cat dander sensitization, and IBS-like symptoms in atopic patients. Future studies are needed to explore the relationship between aeroallergen and functional gastrointestinal disorders. Sensitization may be related to the pathophysiology of IBS or it could be that we are missing aeroallergen-induced gut allergy. © 2020 The Korean Society of Neurogastroenterology and Motility-
dc.languageeng-
dc.publisherKorean Society of Neurogastroenterology and Motility. The Journal's web site is located at http://www.jnmjournal.org/-
dc.relation.ispartofJournal of Neurogastroenterology and Motility-
dc.rightsJournal of Neurogastroenterology and Motility. Copyright © Korean Society of Neurogastroenterology and Motility.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAllergens-
dc.subjectAllergy and immunology-
dc.subjectFel d1 protein-
dc.subjectIrritable bowel syndrome-
dc.titleAtopic Patients Who Fulfilled Rome III Criteria for Irritable Bowel Syndrome Had Higher Animal Danders Sensitization-
dc.typeArticle-
dc.identifier.emailCheung, CKY: ckyc@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5056/jnm19181-
dc.identifier.pmid32235034-
dc.identifier.pmcidPMC7176502-
dc.identifier.scopuseid_2-s2.0-85090371485-
dc.identifier.hkuros318308-
dc.identifier.volume26-
dc.identifier.issue2-
dc.identifier.spage267-
dc.identifier.epage273-
dc.identifier.isiWOS:000523266700012-
dc.publisher.placeRepublic of Korea-
dc.identifier.issnl2093-0879-

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