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Article: The lipid-lowering effect of once-daily soya drink fortified with phytosterols in normocholesterolaemic Chinese: a double-blind randomized controlled trial

TitleThe lipid-lowering effect of once-daily soya drink fortified with phytosterols in normocholesterolaemic Chinese: a double-blind randomized controlled trial
Authors
KeywordsCholesterol
Phytosterol
Plant sterol
Dyslipidemia
LDL
Issue Date2020
PublisherSpringer (part of Springer Nature): Springer Open Choice Hybrid Journals. The Journal's web site is located at http://www.springer.com/steinkopff/journal/394
Citation
European Journal of Nutrition, 2020, v. 59 n. 6, p. 2739-2746 How to Cite?
AbstractPurpose Phytosterols reduce intestinal cholesterol absorption and help to lower LDL-cholesterol. Many Chinese adults are lactose-intolerant and cannot tolerate bovine milk enriched with phytosterol. Soya-milk is a common beverage in Asia and it has beneficial effects on general health. We therefore conducted a randomized double-blind controlled trial to assess the effectiveness of a phytosterols-enriched soya drink in lowering serum LDL-cholesterol level (primary outcome) and other cardiovascular parameters (secondary outcomes). Methods One hundred and fifty-nine normocholesterolaemic participants (85 men and 74 women; aged 19–79) were randomized to daily intake of one serving of phytosterols-enriched soya drink (N = 82), equivalent to 2 g of phytosterol per day, or a matched soya drink without phytosterols (N = 77) for 3 weeks. Adverse events, withdrawal and compliance were documented. Results Among the treatment group (N = 82), phytosterols-enriched soya drink significantly decreased LDL-cholesterol by 5.96% (SE 1.48, 95% CI − 8.91%, − 3.00%) with a median of 6.74% compared with baseline, resulting in a significant reduction of 4.70% (95% CI − 8.89%, − 0.51%; p = 0.028) with a median of 5.20% compared with placebo (N = 77). In contrast, there were no significant changes in other lipid parameters, blood glucose, blood pressure, body weight or waist circumference. Remarkably, 95% of the participants randomized to the fortified drink reported no adverse events at all. Conclusions Daily consumption of a phytosterols-enriched soya drink may be a simple and cost-neutral means of lowering LDL-cholesterol in individuals in China, with massive population and rising incidence of coronary heart disease (ClinicalTrials.gov identifier: NCT02881658; date of registration: 14 Aug 2016).
Persistent Identifierhttp://hdl.handle.net/10722/290944
ISSN
2020 Impact Factor: 5.614
2015 SCImago Journal Rankings: 1.337
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChau, YP-
dc.contributor.authorCheng, YC-
dc.contributor.authorSing, CW-
dc.contributor.authorTsoi, MF-
dc.contributor.authorCheng, VKF-
dc.contributor.authorLee, KY-
dc.contributor.authorCheung, CL-
dc.contributor.authorCheung, BMY-
dc.date.accessioned2020-11-02T05:49:19Z-
dc.date.available2020-11-02T05:49:19Z-
dc.date.issued2020-
dc.identifier.citationEuropean Journal of Nutrition, 2020, v. 59 n. 6, p. 2739-2746-
dc.identifier.issn1436-6207-
dc.identifier.urihttp://hdl.handle.net/10722/290944-
dc.description.abstractPurpose Phytosterols reduce intestinal cholesterol absorption and help to lower LDL-cholesterol. Many Chinese adults are lactose-intolerant and cannot tolerate bovine milk enriched with phytosterol. Soya-milk is a common beverage in Asia and it has beneficial effects on general health. We therefore conducted a randomized double-blind controlled trial to assess the effectiveness of a phytosterols-enriched soya drink in lowering serum LDL-cholesterol level (primary outcome) and other cardiovascular parameters (secondary outcomes). Methods One hundred and fifty-nine normocholesterolaemic participants (85 men and 74 women; aged 19–79) were randomized to daily intake of one serving of phytosterols-enriched soya drink (N = 82), equivalent to 2 g of phytosterol per day, or a matched soya drink without phytosterols (N = 77) for 3 weeks. Adverse events, withdrawal and compliance were documented. Results Among the treatment group (N = 82), phytosterols-enriched soya drink significantly decreased LDL-cholesterol by 5.96% (SE 1.48, 95% CI − 8.91%, − 3.00%) with a median of 6.74% compared with baseline, resulting in a significant reduction of 4.70% (95% CI − 8.89%, − 0.51%; p = 0.028) with a median of 5.20% compared with placebo (N = 77). In contrast, there were no significant changes in other lipid parameters, blood glucose, blood pressure, body weight or waist circumference. Remarkably, 95% of the participants randomized to the fortified drink reported no adverse events at all. Conclusions Daily consumption of a phytosterols-enriched soya drink may be a simple and cost-neutral means of lowering LDL-cholesterol in individuals in China, with massive population and rising incidence of coronary heart disease (ClinicalTrials.gov identifier: NCT02881658; date of registration: 14 Aug 2016).-
dc.languageeng-
dc.publisherSpringer (part of Springer Nature): Springer Open Choice Hybrid Journals. The Journal's web site is located at http://www.springer.com/steinkopff/journal/394-
dc.relation.ispartofEuropean Journal of Nutrition-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in European Journal of Nutrition. The final authenticated version is available online at: https://doi.org/10.1007/s00394-019-02119-w-
dc.subjectCholesterol-
dc.subjectPhytosterol-
dc.subjectPlant sterol-
dc.subjectDyslipidemia-
dc.subjectLDL-
dc.titleThe lipid-lowering effect of once-daily soya drink fortified with phytosterols in normocholesterolaemic Chinese: a double-blind randomized controlled trial-
dc.typeArticle-
dc.identifier.emailSing, CW: cwsing@connect.hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, CL=rp01749-
dc.identifier.authorityCheung, BMY=rp01321-
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00394-019-02119-w-
dc.identifier.pmid31642984-
dc.identifier.scopuseid_2-s2.0-85074582149-
dc.identifier.hkuros318470-
dc.identifier.hkuros317643-
dc.identifier.volume59-
dc.identifier.issue6-
dc.identifier.spage2739-
dc.identifier.epage2746-
dc.identifier.isiWOS:000492015000005-
dc.publisher.placeGermany-
dc.identifier.issnl1436-6207-

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