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- Publisher Website: 10.1084/jem.151.6.1493
- Scopus: eid_2-s2.0-0018836290
- PMID: 6247414
- WOS: WOS:A1980JV38500014
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Article: Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus
Title | Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus |
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Authors | |
Issue Date | 1980 |
Citation | Journal of Experimental Medicine, 1980, v. 151, n. 6, p. 1493-1503 How to Cite? |
Abstract | In this study, the biological properties of the replication-competent viruses, F-MuLV(A), present in the anemia-inducing isolate of Friend leukemia virus complex (FV-A); and F-MuLV(P), present in the polycythemia-inducing isolate of Friend leukemia virus complex (FV-P) have been examined. BALB/c mice infected as newborns with clonal isolates of F-MuLV(A) or F-MuLV(P) become anemic and show splenic enlargement characterized by an increased proportion of cells that resemble immature nucleated erythroid cells. In addition, the spleens of these F-MuLV(A)- or F-MuLV(P)-infected mice contain a markedly increased proportion of both erythropoietin-dependent erythroid progenitor cells and spectrin-containing erythroid cells. These results suggest that Friend murine leukemia virus (F-MuLV) by itself can induce an erythroleukemic transformation in newborn BALB/c mice similar to that induced by the anemia-inducing spleen focus-forming virus (SFFV(A)) in newborn or adult mice. Kinetic studies indicated that the alterations in hemopoietic cell populations induced by F-MuLV(A) or F-MuLV(P) in newborn BALB/c mice occurred more slowly than the rapid changes observed after infection with FV-A. In addition, adult BALB/c mice were fully susceptible to the erythroleukemic transformation induced by either SFFV(A) or SFFV(P), whereas only newborn mice were susceptible to F-MuLV. Taken together, these results suggest that, although the replication-defective Friend spleen focus-forming viruses appear to be the major determinant of erythroleukemia induction in adults, the replication-competent helper F-MuLV also have erythroleukemic potential when assayed in newborn animals. |
Persistent Identifier | http://hdl.handle.net/10722/291377 |
ISSN | 2023 Impact Factor: 12.6 2023 SCImago Journal Rankings: 6.838 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | MacDonald, M. E. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Bernstein, A. | - |
dc.date.accessioned | 2020-11-17T14:54:14Z | - |
dc.date.available | 2020-11-17T14:54:14Z | - |
dc.date.issued | 1980 | - |
dc.identifier.citation | Journal of Experimental Medicine, 1980, v. 151, n. 6, p. 1493-1503 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291377 | - |
dc.description.abstract | In this study, the biological properties of the replication-competent viruses, F-MuLV(A), present in the anemia-inducing isolate of Friend leukemia virus complex (FV-A); and F-MuLV(P), present in the polycythemia-inducing isolate of Friend leukemia virus complex (FV-P) have been examined. BALB/c mice infected as newborns with clonal isolates of F-MuLV(A) or F-MuLV(P) become anemic and show splenic enlargement characterized by an increased proportion of cells that resemble immature nucleated erythroid cells. In addition, the spleens of these F-MuLV(A)- or F-MuLV(P)-infected mice contain a markedly increased proportion of both erythropoietin-dependent erythroid progenitor cells and spectrin-containing erythroid cells. These results suggest that Friend murine leukemia virus (F-MuLV) by itself can induce an erythroleukemic transformation in newborn BALB/c mice similar to that induced by the anemia-inducing spleen focus-forming virus (SFFV(A)) in newborn or adult mice. Kinetic studies indicated that the alterations in hemopoietic cell populations induced by F-MuLV(A) or F-MuLV(P) in newborn BALB/c mice occurred more slowly than the rapid changes observed after infection with FV-A. In addition, adult BALB/c mice were fully susceptible to the erythroleukemic transformation induced by either SFFV(A) or SFFV(P), whereas only newborn mice were susceptible to F-MuLV. Taken together, these results suggest that, although the replication-defective Friend spleen focus-forming viruses appear to be the major determinant of erythroleukemia induction in adults, the replication-competent helper F-MuLV also have erythroleukemic potential when assayed in newborn animals. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Experimental Medicine | - |
dc.title | Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1084/jem.151.6.1493 | - |
dc.identifier.pmid | 6247414 | - |
dc.identifier.pmcid | PMC2185877 | - |
dc.identifier.scopus | eid_2-s2.0-0018836290 | - |
dc.identifier.volume | 151 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1493 | - |
dc.identifier.epage | 1503 | - |
dc.identifier.isi | WOS:A1980JV38500014 | - |
dc.identifier.issnl | 0022-1007 | - |