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- Scopus: eid_2-s2.0-0030459359
- PMID: 8943410
- WOS: WOS:A1996VU50100037
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Article: Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette-Guérin-Induced Granuloma Formation Is Inhibited in TNF Receptor I (TNF-RI) Knockout Mice and by Treatment with Soluble TNF-RI
Title | Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette-Guérin-Induced Granuloma Formation Is Inhibited in TNF Receptor I (TNF-RI) Knockout Mice and by Treatment with Soluble TNF-RI |
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Authors | |
Issue Date | 1996 |
Citation | Journal of Immunology, 1996, v. 157, n. 11, p. 5022-5026 How to Cite? |
Abstract | The aim of this study was to examine the role of TNF receptor I (TNF-RI) in the pathogenesis of heat-killed Corynebacterium parvum- and live bacillus Calmette-Guérin (BCG)-induced granulomas. Granuloma formation was analyzed in TNF-RI knockout mice and after treatment with soluble TNF-RI (sTNF-RI). TNF-RI knockout mice injected with C. parvum or BCG developed fewer and smaller granulomas than wild-type control mice. Mice treated with sTNF-RI from days 7 to 13 after injection of C. parvum or BCG developed fewer and smaller granulomas than saline-treated control mice. Established granulomas regressed in rats treated with sTNF-RI from days 10 to 13 after injection of C. parvum. In conclusion, TNF signaling via TNF-RI contributes to the pathogenesis of C.parvum- and BCG-induced granulomas. sTNF-RI inhibits the development of granulomas and can cause the regression of established granulomas. |
Persistent Identifier | http://hdl.handle.net/10722/291384 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Senaldi, Giorgio | - |
dc.contributor.author | Yin, Songmei | - |
dc.contributor.author | Shaklee, Christine L. | - |
dc.contributor.author | Piguet, Pierre François | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Ulich, Thomas R. | - |
dc.date.accessioned | 2020-11-17T14:54:15Z | - |
dc.date.available | 2020-11-17T14:54:15Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Journal of Immunology, 1996, v. 157, n. 11, p. 5022-5026 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291384 | - |
dc.description.abstract | The aim of this study was to examine the role of TNF receptor I (TNF-RI) in the pathogenesis of heat-killed Corynebacterium parvum- and live bacillus Calmette-Guérin (BCG)-induced granulomas. Granuloma formation was analyzed in TNF-RI knockout mice and after treatment with soluble TNF-RI (sTNF-RI). TNF-RI knockout mice injected with C. parvum or BCG developed fewer and smaller granulomas than wild-type control mice. Mice treated with sTNF-RI from days 7 to 13 after injection of C. parvum or BCG developed fewer and smaller granulomas than saline-treated control mice. Established granulomas regressed in rats treated with sTNF-RI from days 10 to 13 after injection of C. parvum. In conclusion, TNF signaling via TNF-RI contributes to the pathogenesis of C.parvum- and BCG-induced granulomas. sTNF-RI inhibits the development of granulomas and can cause the regression of established granulomas. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Immunology | - |
dc.title | Corynebacterium parvum- and Mycobacterium bovis Bacillus Calmette-Guérin-Induced Granuloma Formation Is Inhibited in TNF Receptor I (TNF-RI) Knockout Mice and by Treatment with Soluble TNF-RI | - |
dc.type | Article | - |
dc.identifier.pmid | 8943410 | - |
dc.identifier.scopus | eid_2-s2.0-0030459359 | - |
dc.identifier.volume | 157 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 5022 | - |
dc.identifier.epage | 5026 | - |
dc.identifier.isi | WOS:A1996VU50100037 | - |
dc.identifier.issnl | 0022-1767 | - |