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Article: Role for IL-15/IL-15 Receptor β-Chain in Natural Killer 1.1+ T Cell Receptor-αβ+ Cell Development

TitleRole for IL-15/IL-15 Receptor β-Chain in Natural Killer 1.1<sup>+</sup> T Cell Receptor-αβ<sup>+</sup> Cell Development
Authors
Issue Date1997
Citation
Journal of Immunology, 1997, v. 159, n. 12, p. 5931-5935 How to Cite?
AbstractMouse TCRαβ+ cells expressing NKR-P1 (NK1+ T cells in the C57BL/6 strain) are classified as a unique subset that require β2m-associated, MHC class I-like molecules for development and preferentially express particular Vβ and VαJ domains of the TCR. We show here that NK1+ T cells express the IL-2Rβ/IL-15Rβ that is normally present on conventional NK cells, but not T cells. In mice lacking IL-2Rβ/IL-15Rβ chain, the number of NK1+ T cells is dramatically reduced. However, in IL-2-deficient mice, NK1+ T cells develop normally. Moreover, NK1+ T cells proliferate upon stimulation by IL-15, and the proliferation is blocked by the addition of anti-IL-2Rβ/IL-15Rβ Abs. Collectively, our data indicate that NK1+ T cells require IL-2Rβ/IL-15Rβ chain in an IL-2-independent manner and demonstrate that IL-15 plays a crucial role during development.
Persistent Identifierhttp://hdl.handle.net/10722/291433
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOhteki, Toshiaki-
dc.contributor.authorHo, Shirley-
dc.contributor.authorSuzuki, Haruhiko-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorOhashi, Pamela S.-
dc.date.accessioned2020-11-17T14:54:21Z-
dc.date.available2020-11-17T14:54:21Z-
dc.date.issued1997-
dc.identifier.citationJournal of Immunology, 1997, v. 159, n. 12, p. 5931-5935-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/291433-
dc.description.abstractMouse TCRαβ+ cells expressing NKR-P1 (NK1+ T cells in the C57BL/6 strain) are classified as a unique subset that require β2m-associated, MHC class I-like molecules for development and preferentially express particular Vβ and VαJ domains of the TCR. We show here that NK1+ T cells express the IL-2Rβ/IL-15Rβ that is normally present on conventional NK cells, but not T cells. In mice lacking IL-2Rβ/IL-15Rβ chain, the number of NK1+ T cells is dramatically reduced. However, in IL-2-deficient mice, NK1+ T cells develop normally. Moreover, NK1+ T cells proliferate upon stimulation by IL-15, and the proliferation is blocked by the addition of anti-IL-2Rβ/IL-15Rβ Abs. Collectively, our data indicate that NK1+ T cells require IL-2Rβ/IL-15Rβ chain in an IL-2-independent manner and demonstrate that IL-15 plays a crucial role during development.-
dc.languageeng-
dc.relation.ispartofJournal of Immunology-
dc.titleRole for IL-15/IL-15 Receptor β-Chain in Natural Killer 1.1<sup>+</sup> T Cell Receptor-αβ<sup>+</sup> Cell Development-
dc.typeArticle-
dc.identifier.pmid9550390-
dc.identifier.scopuseid_2-s2.0-0031573550-
dc.identifier.volume159-
dc.identifier.issue12-
dc.identifier.spage5931-
dc.identifier.epage5935-
dc.identifier.isiWOS:000071914900023-
dc.identifier.issnl0022-1767-

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