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- Publisher Website: 10.1046/j.1523-1747.1998.00214.x
- Scopus: eid_2-s2.0-0031834196
- PMID: 9620306
- WOS: WOS:000073697600019
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Article: Requirement of the IL-2 receptor β chain for the development of Vγ3 dendritic epidermal T cells
Title | Requirement of the IL-2 receptor β chain for the development of Vγ3 dendritic epidermal T cells |
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Authors | |
Keywords | T cell development IL-15 γδ T cells |
Issue Date | 1998 |
Citation | Journal of Investigative Dermatology, 1998, v. 110, n. 6, p. 961-965 How to Cite? |
Abstract | Vγ3 TCR cells develop in the fetal thymus and migrate to the skin as dendritic epidermal T cells (DETC). Fetal Vγ3 thymocytes differentiate from immature heat stable antigen (HSA)(high) cells to mature HSA(low) cells and the latter subset predominantly expresses IL-2 receptor β chain (IL-2Rβ). In this study, the role of IL-2Rβ in the development of Vγ3 cells was determined in IL-2Rβ-deficient mice. There was a moderate reduction of mature HSA(low) Vγ3 thymocytes in IL-2Rβ-deficient mice. Small numbers of Vγ3 DETC were detected in the fetal skin of IL-2Rβ-deficient mice, but they were absent in newborn and adult mice. These results suggest that IL-2Rβ may transduce the crucial signal for survival and/or expansion of Vγ3 cells in the fetal thymus and in the fetal skin. In normal mice, IL-15 but not IL-2 mRNA was expressed in the fetal epidermis and exogenous addition of low concentration of IL-15 to fetal skin organ culture induced proliferation of Vγ3 DETC. The dependence of fetal Vγ3 DETC on the expression of IL-2Rβ and the presence of IL-15 mRNA in the fetal epidermis imply an essential role of IL-15 signaling through IL-2Rβ in the selective localization of this γδ T cell subpopulation in the skin. |
Persistent Identifier | http://hdl.handle.net/10722/291442 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.459 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kawai, K. | - |
dc.contributor.author | Suzuki, H. | - |
dc.contributor.author | Tomiyama, K. | - |
dc.contributor.author | Minagawa, M. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Ohashi, P. S. | - |
dc.date.accessioned | 2020-11-17T14:54:22Z | - |
dc.date.available | 2020-11-17T14:54:22Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Journal of Investigative Dermatology, 1998, v. 110, n. 6, p. 961-965 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | http://hdl.handle.net/10722/291442 | - |
dc.description.abstract | Vγ3 TCR cells develop in the fetal thymus and migrate to the skin as dendritic epidermal T cells (DETC). Fetal Vγ3 thymocytes differentiate from immature heat stable antigen (HSA)(high) cells to mature HSA(low) cells and the latter subset predominantly expresses IL-2 receptor β chain (IL-2Rβ). In this study, the role of IL-2Rβ in the development of Vγ3 cells was determined in IL-2Rβ-deficient mice. There was a moderate reduction of mature HSA(low) Vγ3 thymocytes in IL-2Rβ-deficient mice. Small numbers of Vγ3 DETC were detected in the fetal skin of IL-2Rβ-deficient mice, but they were absent in newborn and adult mice. These results suggest that IL-2Rβ may transduce the crucial signal for survival and/or expansion of Vγ3 cells in the fetal thymus and in the fetal skin. In normal mice, IL-15 but not IL-2 mRNA was expressed in the fetal epidermis and exogenous addition of low concentration of IL-15 to fetal skin organ culture induced proliferation of Vγ3 DETC. The dependence of fetal Vγ3 DETC on the expression of IL-2Rβ and the presence of IL-15 mRNA in the fetal epidermis imply an essential role of IL-15 signaling through IL-2Rβ in the selective localization of this γδ T cell subpopulation in the skin. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Investigative Dermatology | - |
dc.subject | T cell development | - |
dc.subject | IL-15 | - |
dc.subject | γδ T cells | - |
dc.title | Requirement of the IL-2 receptor β chain for the development of Vγ3 dendritic epidermal T cells | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1046/j.1523-1747.1998.00214.x | - |
dc.identifier.pmid | 9620306 | - |
dc.identifier.scopus | eid_2-s2.0-0031834196 | - |
dc.identifier.volume | 110 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 961 | - |
dc.identifier.epage | 965 | - |
dc.identifier.isi | WOS:000073697600019 | - |
dc.identifier.issnl | 0022-202X | - |