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Article: The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

TitleThe transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
Authors
Issue Date1998
Citation
Immunity, 1998, v. 8, n. 1, p. 115-124 How to Cite?
AbstractNF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1(-/-) mutant ES cell lines. NF-ATc1(-/-)/RAG- 1(-/-) chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response.
Persistent Identifierhttp://hdl.handle.net/10722/291448
ISSN
2020 Impact Factor: 31.745
2020 SCImago Journal Rankings: 14.286
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoshida, Hiroki-
dc.contributor.authorNishina, Hiroshi-
dc.contributor.authorTakimoto, Hiroaki-
dc.contributor.authorMarengère, Luc E.M.-
dc.contributor.authorWakeham, Andrew C.-
dc.contributor.authorBouchard, Denis-
dc.contributor.authorKong, Young Yun-
dc.contributor.authorOhteki, Toshiaki-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorBachmann, Martin-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorPenninger, Josef M.-
dc.contributor.authorCrabtree, Gerald R.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:23Z-
dc.date.available2020-11-17T14:54:23Z-
dc.date.issued1998-
dc.identifier.citationImmunity, 1998, v. 8, n. 1, p. 115-124-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/291448-
dc.description.abstractNF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)-deficient blastocyst complementation assays using homozygous NF-ATc1(-/-) mutant ES cell lines. NF-ATc1(-/-)/RAG- 1(-/-) chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.titleThe transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1074-7613(00)80464-1-
dc.identifier.pmid9462517-
dc.identifier.scopuseid_2-s2.0-0031951071-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.spage115-
dc.identifier.epage124-
dc.identifier.isiWOS:000071765700012-
dc.identifier.issnl1074-7613-

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