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Article: Requirement of the CD8 + or CD4 + T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts

TitleRequirement of the CD8 + or CD4 + T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts
Authors
KeywordsKnockout mice
CD4
Tumor rejection
CD8
Issue Date1998
Citation
Immunology Letters, 1998, v. 61, n. 2-3, p. 187-190 How to Cite?
AbstractRejections of the retrovirus induced lymphomas (ALC and RBL-5) and the methylcholanthrene (MCA) induced fibrosarcoma (MC57X) grafts were tested in syngeneic CD8 and CD4 single and double knockout C57BL/6 mice. The results with the lymphomas showed that the CD8 + T cell deficiency prevented the development of rejection response induced by immunization. Deficiency of the CD4 + T subset abrogated also the rejection of ALC. Immunity against the fibrosarcoma cells developed in both type of single knockout mice, but not in the ones which lacked both CD4 + and CD8 + T cells. Thus CD8 + T cells were required for rejection of the lymphoma cells, while the CD4 + T cells only mediated a weak response. In absence of CD8 + T cells, CD4 + T cells were sufficient to reject the fibrosarcoma cells.
Persistent Identifierhttp://hdl.handle.net/10722/291450
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 1.020
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWen, Tao-
dc.contributor.authorTrümper, Lorenz-
dc.contributor.authorFung-Leung, Waiping-
dc.contributor.authorRahemtulla, Amin-
dc.contributor.authorKlein, Eva-
dc.contributor.authorKlein, George-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:23Z-
dc.date.available2020-11-17T14:54:23Z-
dc.date.issued1998-
dc.identifier.citationImmunology Letters, 1998, v. 61, n. 2-3, p. 187-190-
dc.identifier.issn0165-2478-
dc.identifier.urihttp://hdl.handle.net/10722/291450-
dc.description.abstractRejections of the retrovirus induced lymphomas (ALC and RBL-5) and the methylcholanthrene (MCA) induced fibrosarcoma (MC57X) grafts were tested in syngeneic CD8 and CD4 single and double knockout C57BL/6 mice. The results with the lymphomas showed that the CD8 + T cell deficiency prevented the development of rejection response induced by immunization. Deficiency of the CD4 + T subset abrogated also the rejection of ALC. Immunity against the fibrosarcoma cells developed in both type of single knockout mice, but not in the ones which lacked both CD4 + and CD8 + T cells. Thus CD8 + T cells were required for rejection of the lymphoma cells, while the CD4 + T cells only mediated a weak response. In absence of CD8 + T cells, CD4 + T cells were sufficient to reject the fibrosarcoma cells.-
dc.languageeng-
dc.relation.ispartofImmunology Letters-
dc.subjectKnockout mice-
dc.subjectCD4-
dc.subjectTumor rejection-
dc.subjectCD8-
dc.titleRequirement of the CD8 + or CD4 + T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-2478(98)00022-4-
dc.identifier.pmid9657273-
dc.identifier.scopuseid_2-s2.0-0032052765-
dc.identifier.volume61-
dc.identifier.issue2-3-
dc.identifier.spage187-
dc.identifier.epage190-
dc.identifier.isiWOS:000073936800017-
dc.identifier.issnl0165-2478-

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