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- Publisher Website: 10.1126/science.284.5411.156
- Scopus: eid_2-s2.0-0033515883
- PMID: 10102818
- WOS: WOS:000079509000057
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Article: Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
Title | Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition |
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Authors | |
Issue Date | 1999 |
Citation | Science, 1999, v. 284, n. 5411, p. 156-159 How to Cite? |
Abstract | The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase- 9 and its cofactor Apaf-1 were found to be essential downstream components of p53 in Myc-induced apoptosis. Like p53 null cells, mouse embryo fibroblast cells deficient in Apaf-1 and caspase-9, and expressing c-Myc, were resistant to apoptotic stimuli that mimic conditions in developing tumors. Inactivation of Apaf-1 or caspase-9 substituted for p53 loss in promoting the oncogenic transformation of Myc-expressing cells. These results imply a role for Apaf- 1 and caspase-9 in controlling tumor development. |
Persistent Identifier | http://hdl.handle.net/10722/291495 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Soengas, M. S. | - |
dc.contributor.author | Alarcón, R. M. | - |
dc.contributor.author | Yoshida, H. | - |
dc.contributor.author | Giaccia, A. J. | - |
dc.contributor.author | Hakem, R. | - |
dc.contributor.author | Mak, T. W. | - |
dc.contributor.author | Lowe, S. W. | - |
dc.date.accessioned | 2020-11-17T14:54:29Z | - |
dc.date.available | 2020-11-17T14:54:29Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Science, 1999, v. 284, n. 5411, p. 156-159 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291495 | - |
dc.description.abstract | The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase- 9 and its cofactor Apaf-1 were found to be essential downstream components of p53 in Myc-induced apoptosis. Like p53 null cells, mouse embryo fibroblast cells deficient in Apaf-1 and caspase-9, and expressing c-Myc, were resistant to apoptotic stimuli that mimic conditions in developing tumors. Inactivation of Apaf-1 or caspase-9 substituted for p53 loss in promoting the oncogenic transformation of Myc-expressing cells. These results imply a role for Apaf- 1 and caspase-9 in controlling tumor development. | - |
dc.language | eng | - |
dc.relation.ispartof | Science | - |
dc.title | Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1126/science.284.5411.156 | - |
dc.identifier.pmid | 10102818 | - |
dc.identifier.scopus | eid_2-s2.0-0033515883 | - |
dc.identifier.volume | 284 | - |
dc.identifier.issue | 5411 | - |
dc.identifier.spage | 156 | - |
dc.identifier.epage | 159 | - |
dc.identifier.isi | WOS:000079509000057 | - |
dc.identifier.issnl | 0036-8075 | - |