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- Publisher Website: 10.1016/S0002-9440(10)64519-1
- Scopus: eid_2-s2.0-0033870599
- PMID: 10880378
- WOS: WOS:000088089500012
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Article: PECAM-1 (CD31) expression modulates bleeding time in vivo
Title | PECAM-1 (CD31) expression modulates bleeding time in vivo |
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Authors | |
Issue Date | 2000 |
Citation | American Journal of Pathology, 2000, v. 157, n. 1, p. 75-81 How to Cite? |
Abstract | PECAM-1 is a 130-kd member of the Ig superfamily present on endothelial cells, platelets, polymorpho-nuclear leukocytes, monocytes, and lymphocytes. Its expression begins early in development and persists through adulthood. PECAM-1 functions as an adhesion and signaling molecule between adjacent endothelial cells and between endothelial cells and circulating blood elements. Antibodies directed against PECAM-1 have been shown to affect angiogenesis, endothelial cell migration, and polymorphonuclear leukocyte transmigration. Furthermore, its dimerization is associated with the modulation of integrin affinity. Antibody inhibition studies suggest that PECAM-1 plays a role in modulating thrombosis; however, recent in vitro aggregation studies performed on platelets harvested from PECAM-1-deficient mice revealed no abnormalities. In this report we demonstrate prolonged in vivo bleeding times in PECAM-1-deficient mice. This abnormality was not corrected when wild-type hematopoietic precursors were engrafted into marrow-ablated PECAM-1-deficient mice. Furthermore, normal bleeding times were observed when marrow-ablated wild-type mice were engrafted with hematopoietic precursors harvested from PECAM-1-deficient mice. These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression. |
Persistent Identifier | http://hdl.handle.net/10722/291521 |
ISSN | 2021 Impact Factor: 5.770 2020 SCImago Journal Rankings: 1.589 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mahooti, Sepi | - |
dc.contributor.author | Graesser, Donnasue | - |
dc.contributor.author | Patil, Sonali | - |
dc.contributor.author | Newman, Peter | - |
dc.contributor.author | Duncan, Gordon | - |
dc.contributor.author | Mak, Tak | - |
dc.contributor.author | Madri, Joseph A. | - |
dc.date.accessioned | 2020-11-17T14:54:33Z | - |
dc.date.available | 2020-11-17T14:54:33Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | American Journal of Pathology, 2000, v. 157, n. 1, p. 75-81 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291521 | - |
dc.description.abstract | PECAM-1 is a 130-kd member of the Ig superfamily present on endothelial cells, platelets, polymorpho-nuclear leukocytes, monocytes, and lymphocytes. Its expression begins early in development and persists through adulthood. PECAM-1 functions as an adhesion and signaling molecule between adjacent endothelial cells and between endothelial cells and circulating blood elements. Antibodies directed against PECAM-1 have been shown to affect angiogenesis, endothelial cell migration, and polymorphonuclear leukocyte transmigration. Furthermore, its dimerization is associated with the modulation of integrin affinity. Antibody inhibition studies suggest that PECAM-1 plays a role in modulating thrombosis; however, recent in vitro aggregation studies performed on platelets harvested from PECAM-1-deficient mice revealed no abnormalities. In this report we demonstrate prolonged in vivo bleeding times in PECAM-1-deficient mice. This abnormality was not corrected when wild-type hematopoietic precursors were engrafted into marrow-ablated PECAM-1-deficient mice. Furthermore, normal bleeding times were observed when marrow-ablated wild-type mice were engrafted with hematopoietic precursors harvested from PECAM-1-deficient mice. These studies are consistent with a role for PECAM-1 in modulating thrombosis in the vasculature, which is potentially mediated by endothelial cell PECAM-1 expression. | - |
dc.language | eng | - |
dc.relation.ispartof | American Journal of Pathology | - |
dc.title | PECAM-1 (CD31) expression modulates bleeding time in vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/S0002-9440(10)64519-1 | - |
dc.identifier.pmid | 10880378 | - |
dc.identifier.pmcid | PMC1850208 | - |
dc.identifier.scopus | eid_2-s2.0-0033870599 | - |
dc.identifier.volume | 157 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 75 | - |
dc.identifier.epage | 81 | - |
dc.identifier.isi | WOS:000088089500012 | - |
dc.identifier.f1000 | 13409070 | - |
dc.identifier.issnl | 0002-9440 | - |