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Article: The conserved PI3'K/PTEN/AKt signaling pathway regulates both cell size and survival in Drosophila

TitleThe conserved PI3'K/PTEN/AKt signaling pathway regulates both cell size and survival in Drosophila
Authors
KeywordsPTEN
PI3K
Drosophila
Cell size
PKB
Cell survival
Issue Date2000
Citation
Oncogene, 2000, v. 19, n. 35, p. 3971-3977 How to Cite?
AbstractAkt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3'K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3'K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila.
Persistent Identifierhttp://hdl.handle.net/10722/291544
ISSN
2020 Impact Factor: 9.867
2020 SCImago Journal Rankings: 3.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorScanga, Sam E.-
dc.contributor.authorRuel, Laurent-
dc.contributor.authorBinari, Richard C.-
dc.contributor.authorSnow, Brian-
dc.contributor.authorStambolic, Vuk-
dc.contributor.authorBouchard, Denis-
dc.contributor.authorPeters, Malte-
dc.contributor.authorCalvieri, Batista-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorWoodgett, James R.-
dc.contributor.authorManoukian, Armen S.-
dc.date.accessioned2020-11-17T14:54:36Z-
dc.date.available2020-11-17T14:54:36Z-
dc.date.issued2000-
dc.identifier.citationOncogene, 2000, v. 19, n. 35, p. 3971-3977-
dc.identifier.issn0950-9232-
dc.identifier.urihttp://hdl.handle.net/10722/291544-
dc.description.abstractAkt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3'K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3'K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila.-
dc.languageeng-
dc.relation.ispartofOncogene-
dc.subjectPTEN-
dc.subjectPI3K-
dc.subjectDrosophila-
dc.subjectCell size-
dc.subjectPKB-
dc.subjectCell survival-
dc.titleThe conserved PI3'K/PTEN/AKt signaling pathway regulates both cell size and survival in Drosophila-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.onc.1203739-
dc.identifier.pmid10962553-
dc.identifier.scopuseid_2-s2.0-0034680008-
dc.identifier.volume19-
dc.identifier.issue35-
dc.identifier.spage3971-
dc.identifier.epage3977-
dc.identifier.isiWOS:000088825300002-
dc.identifier.issnl0950-9232-

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