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Article: Regulation of PTEN transcription by p53

TitleRegulation of PTEN transcription by p53
Authors
Issue Date2001
Citation
Molecular Cell, 2001, v. 8, n. 2, p. 317-325 How to Cite?
AbstractPTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3′K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN locus revealed a p53 binding element directly upstream of the PTEN gene. Deletion and mutation analyses showed that this element is necessary for inducible transactivation of PTEN by p53. A p53-independent element controlling constitutive expression of PTEN was also identified. In contrast to p53 mutant cell lines, induction of p53 in primary and tumor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling.
Persistent Identifierhttp://hdl.handle.net/10722/291556
ISSN
2023 Impact Factor: 14.5
2023 SCImago Journal Rankings: 9.332
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStambolic, V.-
dc.contributor.authorMacPherson, D.-
dc.contributor.authorSas, D.-
dc.contributor.authorLin, Y.-
dc.contributor.authorSnow, B.-
dc.contributor.authorJang, Y.-
dc.contributor.authorBenchimol, S.-
dc.contributor.authorMak, T. W.-
dc.date.accessioned2020-11-17T14:54:37Z-
dc.date.available2020-11-17T14:54:37Z-
dc.date.issued2001-
dc.identifier.citationMolecular Cell, 2001, v. 8, n. 2, p. 317-325-
dc.identifier.issn1097-2765-
dc.identifier.urihttp://hdl.handle.net/10722/291556-
dc.description.abstractPTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3′K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN locus revealed a p53 binding element directly upstream of the PTEN gene. Deletion and mutation analyses showed that this element is necessary for inducible transactivation of PTEN by p53. A p53-independent element controlling constitutive expression of PTEN was also identified. In contrast to p53 mutant cell lines, induction of p53 in primary and tumor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling.-
dc.languageeng-
dc.relation.ispartofMolecular Cell-
dc.titleRegulation of PTEN transcription by p53-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1097-2765(01)00323-9-
dc.identifier.pmid11545734-
dc.identifier.scopuseid_2-s2.0-0034854091-
dc.identifier.volume8-
dc.identifier.issue2-
dc.identifier.spage317-
dc.identifier.epage325-
dc.identifier.isiWOS:000170827000009-
dc.identifier.issnl1097-2765-

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