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- Publisher Website: 10.1016/S0959-4388(02)00354-9
- Scopus: eid_2-s2.0-0036801311
- PMID: 12367630
- WOS: WOS:000178693000007
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Article: PTEN function in mammalian cell size regulation
Title | PTEN function in mammalian cell size regulation |
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Authors | |
Issue Date | 2002 |
Citation | Current Opinion in Neurobiology, 2002, v. 12, n. 5, p. 516-522 How to Cite? |
Abstract | The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3′ kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation. |
Persistent Identifier | http://hdl.handle.net/10722/291601 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 2.982 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Backman, Stéphanie A. | - |
dc.contributor.author | Stambolic, Vuk | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:43Z | - |
dc.date.available | 2020-11-17T14:54:43Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Current Opinion in Neurobiology, 2002, v. 12, n. 5, p. 516-522 | - |
dc.identifier.issn | 0959-4388 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291601 | - |
dc.description.abstract | The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3′ kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Opinion in Neurobiology | - |
dc.title | PTEN function in mammalian cell size regulation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0959-4388(02)00354-9 | - |
dc.identifier.pmid | 12367630 | - |
dc.identifier.scopus | eid_2-s2.0-0036801311 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 516 | - |
dc.identifier.epage | 522 | - |
dc.identifier.isi | WOS:000178693000007 | - |
dc.identifier.issnl | 0959-4388 | - |