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Article: Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

TitleCostimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses
Authors
Issue Date2003
Citation
Nature Immunology, 2003, v. 4, n. 8, p. 765-772 How to Cite?
AbstractCostimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl-/- and Icos-/- mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl-/- mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.
Persistent Identifierhttp://hdl.handle.net/10722/291656
ISSN
2020 Impact Factor: 25.606
2020 SCImago Journal Rankings: 9.074
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMak, Tak W.-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorYoshinaga, Steve K.-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorBoucher, Louis Martin-
dc.contributor.authorPintilie, Melania-
dc.contributor.authorDuncan, Gordon-
dc.contributor.authorGajewska, Beata U.-
dc.contributor.authorGronski, Matthew-
dc.contributor.authorEriksson, Urs-
dc.contributor.authorOdermatt, Bernhard-
dc.contributor.authorHo, Alexandra-
dc.contributor.authorBouchard, Denis-
dc.contributor.authorWhorisky, John S.-
dc.contributor.authorJordana, Manel-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorPawson, Tony-
dc.contributor.authorBladt, Friedhelm-
dc.contributor.authorTafuri, Anna-
dc.date.accessioned2020-11-17T14:54:50Z-
dc.date.available2020-11-17T14:54:50Z-
dc.date.issued2003-
dc.identifier.citationNature Immunology, 2003, v. 4, n. 8, p. 765-772-
dc.identifier.issn1529-2908-
dc.identifier.urihttp://hdl.handle.net/10722/291656-
dc.description.abstractCostimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl-/- and Icos-/- mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl-/- mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.-
dc.languageeng-
dc.relation.ispartofNature Immunology-
dc.titleCostimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ni947-
dc.identifier.pmid12833154-
dc.identifier.scopuseid_2-s2.0-0042195831-
dc.identifier.volume4-
dc.identifier.issue8-
dc.identifier.spage765-
dc.identifier.epage772-
dc.identifier.isiWOS:000184441500013-
dc.identifier.issnl1529-2908-

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