File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor

TitleLFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor
Authors
Issue Date1996
Citation
Journal of Experimental Medicine, 1996, v. 183, n. 4, p. 1415-1426 How to Cite?
AbstractThe leukocyte intergrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA- 1-deficient mice did not reject immunogenic tumors grafted into footpads and did not demonstrate priming response against tumor-specific antigen. Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic refection are normal.
Persistent Identifierhttp://hdl.handle.net/10722/291701
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 6.838
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSchmits, Rudolf-
dc.contributor.authorKündig, Thomas M.-
dc.contributor.authorBaker, Dianne M.-
dc.contributor.authorShumaker, Grace-
dc.contributor.authorSimard, John J.L.-
dc.contributor.authorDuncan, Gordon-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorVan Der Heiden, Annette-
dc.contributor.authorBachmann, Martin F.-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorHickstein, Dennis D.-
dc.date.accessioned2020-11-17T14:54:55Z-
dc.date.available2020-11-17T14:54:55Z-
dc.date.issued1996-
dc.identifier.citationJournal of Experimental Medicine, 1996, v. 183, n. 4, p. 1415-1426-
dc.identifier.issn0022-1007-
dc.identifier.urihttp://hdl.handle.net/10722/291701-
dc.description.abstractThe leukocyte intergrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA- 1-deficient mice did not reject immunogenic tumors grafted into footpads and did not demonstrate priming response against tumor-specific antigen. Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic refection are normal.-
dc.languageeng-
dc.relation.ispartofJournal of Experimental Medicine-
dc.titleLFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1084/jem.183.4.1415-
dc.identifier.pmid8666900-
dc.identifier.pmcidPMC2192492-
dc.identifier.scopuseid_2-s2.0-15844379199-
dc.identifier.volume183-
dc.identifier.issue4-
dc.identifier.spage1415-
dc.identifier.epage1426-
dc.identifier.isiWOS:A1996UH14400016-
dc.identifier.issnl0022-1007-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats