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- Publisher Website: 10.1002/(SICI)1521-4141(199910)29:10<3262::AID-IMMU3262>3.0.CO;2-A
- Scopus: eid_2-s2.0-17144450359
- PMID: 10540338
- WOS: WOS:000083141000023
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Article: Homeostatic regulation of CD8+ T cells by perforin
Title | Homeostatic regulation of CD8<sup>+</sup> T cells by perforin |
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Authors | |
Keywords | Cytotoxic T cell Homeostatic regulation Perforin |
Issue Date | 1999 |
Citation | European Journal of Immunology, 1999, v. 29, n. 10, p. 3262-3272 How to Cite? |
Abstract | To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by controlled deletion. Here we show that similar to Fas, perforin is not only an important effector molecule of cytotoxic T lymphocytes (CTL) but also involved in down-regulating peripheral T cells. Mice deficient for both the CTL effector molecule perforin and the apoptosis-inducing Ras ligand spontaneously develop infiltration of highly activated CD8+ T cells in kidney and liver and die between 5 and 12 weeks of age. Injection of staphylococcal enterotoxin B (SEB) into perforin-deficient mice results in dramatically increased selective expansion and prolonged persistence of CD8+, but not CD4+, SEB-reactive T cells. Also, secondary immunization of TCR transgenic perforin-deficient mice with the lymphocytic choriomeningitis virus glycoprotein-derived epitope peptide leads to an increased proliferation of transgenic CD8+ T cells, that is not explained by failure to deplete professional antigen-presenting cells. These results point to a novel mechanism of T cell homeostasis in which the acquisition of perforin-dependent cytotoxic activity regulates the expansion and persistence of CD8+ effector T cells in vivo. |
Persistent Identifier | http://hdl.handle.net/10722/291710 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kägi, David | - |
dc.contributor.author | Odermatt, Bernhard | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:57Z | - |
dc.date.available | 2020-11-17T14:54:57Z | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | European Journal of Immunology, 1999, v. 29, n. 10, p. 3262-3272 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291710 | - |
dc.description.abstract | To prevent uncontrolled expansion, the massive proliferation of T cells during an acute immune response has to be followed by controlled deletion. Here we show that similar to Fas, perforin is not only an important effector molecule of cytotoxic T lymphocytes (CTL) but also involved in down-regulating peripheral T cells. Mice deficient for both the CTL effector molecule perforin and the apoptosis-inducing Ras ligand spontaneously develop infiltration of highly activated CD8+ T cells in kidney and liver and die between 5 and 12 weeks of age. Injection of staphylococcal enterotoxin B (SEB) into perforin-deficient mice results in dramatically increased selective expansion and prolonged persistence of CD8+, but not CD4+, SEB-reactive T cells. Also, secondary immunization of TCR transgenic perforin-deficient mice with the lymphocytic choriomeningitis virus glycoprotein-derived epitope peptide leads to an increased proliferation of transgenic CD8+ T cells, that is not explained by failure to deplete professional antigen-presenting cells. These results point to a novel mechanism of T cell homeostasis in which the acquisition of perforin-dependent cytotoxic activity regulates the expansion and persistence of CD8+ effector T cells in vivo. | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.subject | Cytotoxic T cell | - |
dc.subject | Homeostatic regulation | - |
dc.subject | Perforin | - |
dc.title | Homeostatic regulation of CD8<sup>+</sup> T cells by perforin | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/(SICI)1521-4141(199910)29:10<3262::AID-IMMU3262>3.0.CO;2-A | - |
dc.identifier.pmid | 10540338 | - |
dc.identifier.scopus | eid_2-s2.0-17144450359 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 3262 | - |
dc.identifier.epage | 3272 | - |
dc.identifier.isi | WOS:000083141000023 | - |
dc.identifier.issnl | 0014-2980 | - |