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Article: DJ-1, a novel regulator of the tumor suppressor PTEN

TitleDJ-1, a novel regulator of the tumor suppressor PTEN
Authors
Issue Date2005
Citation
Cancer Cell, 2005, v. 7, n. 3, p. 263-273 How to Cite?
AbstractThe phosphatidylinositol 3′ kinase (PI3′K) pathway, which regulates cell survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of PTEN function. In mammalian cells, DJ-1 underexpression results in decreased phosphorylation of PKB/Akt, while DJ-1 overexpression leads to hyperphosphorylation of PKB/Akt and increased cell survival. In primary breast cancer samples, DJ-1 expression correlates negatively with PTEN immunoreactivity and positively with PKB/Akt hyperphosphorylation. In 19/23 primary non-small cell lung carcinoma samples, DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence. DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer. Copyright © 2005 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/291726
ISSN
2023 Impact Factor: 48.8
2023 SCImago Journal Rankings: 17.507
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKim, Raymond H.-
dc.contributor.authorPeters, Malte-
dc.contributor.authorJang, Yingju-
dc.contributor.authorShi, Wei-
dc.contributor.authorPintilie, Melania-
dc.contributor.authorFletcher, Graham C.-
dc.contributor.authorDeLuca, Carmela-
dc.contributor.authorLiepa, Jennifer-
dc.contributor.authorZhou, Lily-
dc.contributor.authorSnow, Bryan-
dc.contributor.authorBinari, Richard C.-
dc.contributor.authorManoukian, Armen S.-
dc.contributor.authorBray, Mark R.-
dc.contributor.authorLiu, Fei Fei-
dc.contributor.authorTsao, Ming Sound-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:59Z-
dc.date.available2020-11-17T14:54:59Z-
dc.date.issued2005-
dc.identifier.citationCancer Cell, 2005, v. 7, n. 3, p. 263-273-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10722/291726-
dc.description.abstractThe phosphatidylinositol 3′ kinase (PI3′K) pathway, which regulates cell survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of PTEN function. In mammalian cells, DJ-1 underexpression results in decreased phosphorylation of PKB/Akt, while DJ-1 overexpression leads to hyperphosphorylation of PKB/Akt and increased cell survival. In primary breast cancer samples, DJ-1 expression correlates negatively with PTEN immunoreactivity and positively with PKB/Akt hyperphosphorylation. In 19/23 primary non-small cell lung carcinoma samples, DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence. DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer. Copyright © 2005 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofCancer Cell-
dc.titleDJ-1, a novel regulator of the tumor suppressor PTEN-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ccr.2005.02.010-
dc.identifier.pmid15766664-
dc.identifier.scopuseid_2-s2.0-20244365801-
dc.identifier.volume7-
dc.identifier.issue3-
dc.identifier.spage263-
dc.identifier.epage273-
dc.identifier.isiWOS:000227823000009-
dc.identifier.issnl1535-6108-

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