File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

TitleCkap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner
Authors
Issue Date2005
Citation
Cancer Research, 2005, v. 65, n. 15, p. 6685-6691 How to Cite?
AbstractWe used DNA microarray screening to identify Ckap2 (cytoskeleton associated protein 2) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates the Ckap2 promoter. Overexpressed Ckap2 colocalizes with and stabilizes microtubules. In p53-null cells, overexpression of Ckap2 induces tetraploidy with aberrant centrosome numbers, suggesting disturbed mitosis and cytokinesis. In p53-competent cells, Ckap2 does not induce tetraploidy but activates p53-mediated cell cycle arrest and apoptosis. Our data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy. ©2005 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/291737
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsuchihara, Katsuya-
dc.contributor.authorLapin, Valentina-
dc.contributor.authorBakal, Christopher-
dc.contributor.authorOkada, Hitoshi-
dc.contributor.authorBrown, Lauren-
dc.contributor.authorHirota-Tsuchihara, Masami-
dc.contributor.authorZaugg, Kathrin-
dc.contributor.authorHo, Alexandra-
dc.contributor.authorItie-YouTen, Annick-
dc.contributor.authorHarris-Brandts, Marees-
dc.contributor.authorRottapel, Robert-
dc.contributor.authorRichardson, Christopher D.-
dc.contributor.authorBenchimol, Samuel-
dc.contributor.authorMak, Tak Wah-
dc.date.accessioned2020-11-17T14:55:00Z-
dc.date.available2020-11-17T14:55:00Z-
dc.date.issued2005-
dc.identifier.citationCancer Research, 2005, v. 65, n. 15, p. 6685-6691-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/291737-
dc.description.abstractWe used DNA microarray screening to identify Ckap2 (cytoskeleton associated protein 2) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates the Ckap2 promoter. Overexpressed Ckap2 colocalizes with and stabilizes microtubules. In p53-null cells, overexpression of Ckap2 induces tetraploidy with aberrant centrosome numbers, suggesting disturbed mitosis and cytokinesis. In p53-competent cells, Ckap2 does not induce tetraploidy but activates p53-mediated cell cycle arrest and apoptosis. Our data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy. ©2005 American Association for Cancer Research.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleCkap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-04-4223-
dc.identifier.pmid16061649-
dc.identifier.scopuseid_2-s2.0-23044467274-
dc.identifier.volume65-
dc.identifier.issue15-
dc.identifier.spage6685-
dc.identifier.epage6691-
dc.identifier.isiWOS:000230837900028-
dc.identifier.issnl0008-5472-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats