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Article: Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections

TitleValue of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
Authors
KeywordsCRP
Pneumonia
Neopterin
C-reactive protein
Procalcitonin
Lower respiratory tract infection (LRTI)
Issue Date2007
Citation
Diagnostic Microbiology and Infectious Disease, 2007, v. 59, n. 2, p. 131-136 How to Cite?
AbstractThe values of procalcitonin (PCT), neopterin, and C-reactive protein (CRP) alone and in combination to differentiate bacterial from viral etiology in patients with lower respiratory tract infections (LRTIs) were evaluated. Sera obtained on the day of hospitalization for LRTI from 139 patients with confirmed bacterial etiology and 128 patients with viral etiology were examined. A further 146 sera from healthy Chinese subjects with no infection were included as controls. The area under the receiver operating characteristic (ROC) curve (area under curve [AUC]) for distinguishing bacterial from viral infections was 0.838 for CRP and 0.770 for PCT (P < 0.05). The AUC for distinguishing viral from bacterial infections was 0.832 for neopterin (P < 0.05). When the markers were used in combination, AUC of ROC (CRP/neopterin) was 0.857, whereas (CRP × PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/291788
ISSN
2020 Impact Factor: 2.803
2020 SCImago Journal Rankings: 1.027
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, Margaret-
dc.contributor.authorRainer, Timothy H.-
dc.contributor.authorLee, Nelson-
dc.contributor.authorChan, Cangel-
dc.contributor.authorChau, Shirley S.L.-
dc.contributor.authorLeung, Wingman-
dc.contributor.authorLeung, Man Fai-
dc.contributor.authorTam, Tze Kin-
dc.contributor.authorAntonio, Gregory E.-
dc.contributor.authorLui, Grace-
dc.contributor.authorLau, Tze Kin-
dc.contributor.authorHui, David S.C.-
dc.contributor.authorFuchs, Dietmar-
dc.contributor.authorRenneberg, Reinhard-
dc.contributor.authorChan, Paul K.S.-
dc.date.accessioned2020-11-17T14:55:07Z-
dc.date.available2020-11-17T14:55:07Z-
dc.date.issued2007-
dc.identifier.citationDiagnostic Microbiology and Infectious Disease, 2007, v. 59, n. 2, p. 131-136-
dc.identifier.issn0732-8893-
dc.identifier.urihttp://hdl.handle.net/10722/291788-
dc.description.abstractThe values of procalcitonin (PCT), neopterin, and C-reactive protein (CRP) alone and in combination to differentiate bacterial from viral etiology in patients with lower respiratory tract infections (LRTIs) were evaluated. Sera obtained on the day of hospitalization for LRTI from 139 patients with confirmed bacterial etiology and 128 patients with viral etiology were examined. A further 146 sera from healthy Chinese subjects with no infection were included as controls. The area under the receiver operating characteristic (ROC) curve (area under curve [AUC]) for distinguishing bacterial from viral infections was 0.838 for CRP and 0.770 for PCT (P < 0.05). The AUC for distinguishing viral from bacterial infections was 0.832 for neopterin (P < 0.05). When the markers were used in combination, AUC of ROC (CRP/neopterin) was 0.857, whereas (CRP × PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI. © 2007 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease-
dc.subjectCRP-
dc.subjectPneumonia-
dc.subjectNeopterin-
dc.subjectC-reactive protein-
dc.subjectProcalcitonin-
dc.subjectLower respiratory tract infection (LRTI)-
dc.titleValue of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2007.04.019-
dc.identifier.pmid17662560-
dc.identifier.scopuseid_2-s2.0-34748845790-
dc.identifier.volume59-
dc.identifier.issue2-
dc.identifier.spage131-
dc.identifier.epage136-
dc.identifier.isiWOS:000250167100004-
dc.identifier.issnl0732-8893-

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